刘丹，博士生导师、硕士生导师。聚焦复杂生物体系分析，致力于建立靶标选择性富集新策略、发展信号转化与放大新方法，实现痕量物质的高灵敏度、高选择性检测。目前已主持国家自然科学基金（面上项目、青年项目）、福建省自然科学基金、国家重点实验室开放基金、校企产学研项目、泉州市科技计划项目、中青年教师科技创新计划等课题。以第一作者或通讯作者身份在 ACS Nano、Angew Chem Int Ed、Lab Chip、Anal Chem、ACS Appl Mater Inter、Biosens Bioelectron、Sens Actuators 等期刊发表 SCI 论文 20 余篇。获评福建省高层次人才、厦门市高层次人才、泉州市高层次人才；作为核心成员参与获得厦门市科技进步一等奖。
主要研究论文：
1) Liu Dan*, Xiao Lu, Wu Yuyuan, Yue Chensirong, Li Mengmeng, Sun Yuanpei, Yang Chaoyong*. Spatially Resolved Transcriptomics: Revealing Tumor Microenvironment Heterogeneity to Advance Cancer Immunotherapy. Small Methods, 2025, e00770.
2) Liu Dan*; Yu Xingbo; Li Congying; Wang Ying; Huang Chenyi; Li Mengmeng; Huang Yishun*; Yang Chaoyong*. Au-Pt Coating Improved Catalytic Stability of Au@AuPt Nanoparticles for Pressure-Based Point-of-Care Detection of Escherichia coli O157:H7. ACS Applied Materials & Interfaces, 2024, 16(27): 34632-34640.
3) Li Mengmeng; Zhong Yujian; Zhu Mingyang; Pang Chunjin; Xiao Lu; Bu Ye; Li Huapeng; Diao Yong; Yang Chaoyong; Liu Dan*. Identification of new AAV vectors with enhanced blood-brain barrier penetration efficiency via organ-on-a-chip. Analyst, 2024, 149(15):3980-3988.
4) Yu Xingbo; Wang Ying; Wang Kun; Zhu Ziyuan; Xiao Lu; Huang Yishun; Song Yanling; Liu Dan*. Enhanced portable detection for Sars-CoV-2 utilizing DNA tetrahedron-tethered aptamers and a pressure meter. Analytical Methods, 2023, 16(4): 639-644.
5) Huang Ruolan; Liu Kun; Yue Chensirong; Wang Ying; Zeng Zhilong; Xiao Lu; Dong Lei*; Ke Rongqin*; Yang Chaoyong*; Liu Dan*. Chromogenic visualization of single RNA molecules in situ with duplex capability by rolling circle amplification with alkaline phosphatase. Analytical Chemistry, 2023, 95(32): 12161-12168.
6) Wu Qiuyue; Zhu Lin; Wei Xinyu; Zhang Mingxia; Zhang Chi; You Zhenlong; Zhang Suhui; Song Yanling*; Liu Dan*; Yang Chaoyong*. Detection of circulating tumor cells using antibody-functionalized microchips to monitor tumorigenesis in a mouse model of metastatic breast cancer. Sensors and Actuators B: Chemical, 2023, 379:133274.
7) Ling Jiajun#; Liu Dan#; Zhang Jialu #; Zhu Lin; Wan Shuang; Yang Chaoyong; Song Yanling*. Thermodynamic and Kinetic Modulation of Microfluidic Interfaces by DNA Nanoassembly Mediated Merit-Complementary Heteromultivalency. ACS Nano, 2022, 16(12):20915-20921.
8) Liu Dan*; Zhu Mingyang; Lin Yi; Li Mengmeng; Huang Ruolan; Yang Liu*; Song Yanling; Diao Yong; Yang Chaoyong*. LY6E protein facilitates adeno-associated virus crossing in a biomimetic chip model of the human blood-brain barrier. Lab on a Chip, 2022, 22: 4180-4190.
9) Liu, Dan*; Wang Ying; Li, Mengmeng; Wu Qiaoyi*; Song Yanling; Zhu Zhi; Yang Chaoyong*. Integrated microfluidic devices for in vitro diagnostics at point of care. Aggregate, 2022, 3(5): e184.
10) Wang Kun; Huang Ruolan; Zhang Liyun; Liu Dan*; Diao Yong*. Recombinase-Aided Amplification Combined with Lateral Flow (LF-RAA) Assay for Rapid AAV Genome Detection. ACS Omega, 2022, 7(51): 47832-47839.
11) Liu Dan*; Shen Haicong; Zhang Yuqian; Shen Danyu; Zhu Mingyang; Song Yanling; Zhu Zhi; Yang Chaoyong*. A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection. Lab on a Chip, 2021, 21: 2019-2026.
12) Liu Dan; Zhang Yuqian; Zhu Mingyang; Yu Zongzhong; Ma Xiaoming; Song Yanling; Zhou Shufeng*; Yang Chaoyong*. Microfluidic-integrated multicolor immunosensor for visual detection of HIV-1 p24 antigen with the naked eye, Analytical Chemistry, 2020, 92 (17):11826-11833.
13) Liu Dan*; Zhu Mingyang; Zhang Yuqian; Diao Yong. Crossing the blood-brain barrier with AAV vectors. Metabolic Brain Disease, 2021, 36 (1), 45-52.
14) Liu Dan*; Wang Junxia; Wu Lingling; Huang Yishun; Zhang Yuqian; Zhu Mingyang; Wang Yang; Zhu Zhi*; Yang Chaoyong. Trends in miniaturized biosensors for point-of-care testing, TrAC Trends in Analytical Chemistry, 2020,122: 115701.
15) Liu Dan*; Liu Fang; Huang Yishun; Song Yanling; Zhu Zhi; Zhou Shu-feng; Yang Chaoyong*. Catalase-linked immunosorbent pressure assay for portable quantitative analysis, Analyst, 2019, 144 (14): 4188-4193.
16) Liu Dan; Tian Tian; Chen Xiaofeng; Lei Zhichao; Song Yanling; Shi Yuanzhi; Ji Tianhai; Zhu Zhi; Yang Liu; Yang Chaoyong*. Gas-generating reactions for point-of-care testing, Analyst, 2018, 143 (6): 1294-1304.
17) Tao Qian; Wu Xinyi; Lin Qingyuan; Zheng Haiyan; Yang Wensheng; Liu Dan*; Yang Chaoyong James; Ji Tianhai*. Portable detection of serum HER-2 in breast cancer by a pressure-based platform, Analytical and bioanalytical chemistry, 2018, 410 (28): 7489-7498.
18) Liu Dan; Li Xingrui; Zhou Junkai; Liu Shibo; Tian Tian; Song Yanling; Zhu Zhi; Zhou Leiji; Ji Tianhai; Yang Chaoyong*. A fully integrated distance readout ELISA-Chip for point-of-care testing with sample-in-answer-out capability, Biosensors and Bioelectronics, 2017, 96: 332-338.
19) Liu Dan; Jia Shasha; Zhang Huimin; Ma Yanli; Guan Zhichao; Li Jiuxing; Zhu Zhi*; Ji Tianhai; Yang Chaoyong James*. Integrating target-responsive hydrogel with pressuremeter readout enables simple, sensitive, user-friendly, quantitative point-of-care testing, ACS Applied Materials & Interfaces, 2017, 9(27): 22252-22258.
20) Ji Tianhai#; Liu Dan#; Liu Fang; Li Jiuxing; Ruan Qingyu; Song Yanling; Tian Tian; Zhu Zhi; Zhou Leiji; Lin Hui*; Chaoyong Yang; Dong Wang*. A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein, Chemical Communications, 2016, 52 (54): 8452-8454.
21) Zhu Zhi#; Guan Zhichao#; Liu Dan#; Jia Shasha#; Li Jiuxing; Lei Zhichao; Lin Shuichao; Ji Tianhai; Tian Zhongqun; Yang Chaoyong James*. Translating molecular recognition into a pressure signal to enable rapid, sensitive, and portable biomedical analysis, Angewandte Chemie International Edition, 2015, 54 (36): 10448-10453.
22) Liu Dan; Lin Bingqian; Shao Wei; Zhu Zhi; Ji Tianhai*; Yang Chaoyong*. In vitro and in vivo studies on the transport of PEGylated silica nanoparticles across the blood–brain barrier, ACS applied materials & interfaces, 2014, 6 (3): 2131-2136.
23) Liu Dan; He Xiaoxiao*; Wang Kemin*; He Chunmei; Shi Hui; Jian Lixin. Biocompatible silica nanoparticles−insulin conjugates for mesenchymal stem cell adipogenic differentiation, Bioconjugate chemistry, 2010, 21 (9): 1673-1684.
授权发明专利：
1) 刘丹; 杨朝勇; 刁勇; 张语倩; 沈海聪; 成志云. 用于检测COVID-19病毒的RT-RAA引物对和诊断试剂盒, ZL202010578160.X
2) 杨朝勇; 刘丹; 沈海聪; 张语倩; 李博安. 核酸检测的方法及其装置和在COVID-19检测中的应用, ZL202010578157.8
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