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Professor

Supervisor of Master's Candidates

Gender:Male

Date of Birth:1981-05-04

Alma Mater:首都师范大学

Education Level:博士研究生

Degree:Doctoral Degree in Science

Date of Employment:2015-01-30

School/Department:医学院

Business Address:泉州校区医学院427

E-Mail:

Status:在岗

Discipline:Pharmaceutical Chemistry

liu jieqing

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Date of Birth:1981-05-04

Gender:Male

Education Level:博士研究生

Alma Mater:首都师范大学

Paper Publications

Xu, W.-J.; Xiao, Q.; Lian, C.-L.; Zhang, C.; Liu, J.-Q.*, The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E. Steroids 2021, 166, 108776.

Journal:Steroids
Key Words:4β-Hydroxywithanolide E; Cytotoxic activity; Structure modification.
Abstract:4β-Hydroxywithanolide E, which can be obtained in large amounts from the Physalis genus, possessed anti-proliferative effects on a variety of human cancer cell lines. For discussing its anti-tumor structure-activity relationship, a series of 4β-hydroxywithanolide E derivatives (1-17) were synthesized and evaluated for their antitumor activity in vitro towards acute promyelocytic leukemia NB4 cell line by the Alarma blue assay. Cytotoxicity data revealed that the enone structure and C-4 hydroxyl substituents of ring A, together with the side chain (C-20-C-28) play an important effect on the cytotoxicity.
Translation or Not:no
Date of Publication:2019-12-15