学位:理学博士学位
学历:博士研究生
职称:教授
所在单位:JieQing Liu, Professor, Huaqiao University
学术荣誉:
于2003年获吉林大学药学学士,2006年获吉林大学药物化学硕士,2009年获首都师范大学遗传学博士,2009-2011年于中国科学院昆明植物研究所完成博士后研究工作。2018-2019年以高级访问学者赴香港大学交流学习。2015年1月入职华侨大学医学院,现任华侨大学医学院副院长。福建省高层次人才,龙岩市首批创新人才,泉州市高层次(第三层次)人才,云南省中青年学术和技术带头人后备人才,华侨大学 “学生最喜爱的教师”和“师德模范”。泉州市中医药研究促进会会长,福建省中医药研究促进会第六届理事会常务理事,泉州市中医药学会中药分会副会长/常委,福建省微生物学会药用真菌专业委员会常委。
长期从事中药现代化应用研究,药膳与大健康研究,天然药物研究与开发。先后主持国家自然科学基金面上项目、福建省自然科学基金面上项目、福建省高校青年自然基金重点项目、泉州市高端海洋人才资助项目、泉州市科技局项目、福建省高校产学合作项目、校企横向合作项目等。以第一作者或通讯作者在Communications Biology, BMC Cancer, Bioorganic & Medicinal Chemistry, Phytotherapy Research, Journal of Ethnopharmacology, Food & Function, Food Chemistry, Organic Biomolecular Chemistry, Steroids等国际杂志上发表SCI论文60余篇,申请中国发明专利十余项。指导学生获得校级及以上各类科创竞赛或创新项目20余项,包括全国大学生生命科学竞赛一等奖2个、二等奖1个、三等奖2个,第11届全国大学生电子商务“创新、创意及创业”挑战赛三等奖、第七届全国青年科普创新实验暨作品大赛(生物环境组)福建赛区一等奖和三等奖各1个,2023福建省基础医学研究生创新大赛三等奖2个,华侨大学第28届“挑战杯”赛特等奖等。
Liu JQ*, Lian CL, Hu TY, Wang CF, Xu Y, Xiao L, Liu ZQ, Qiu SQ, Cheng BH. Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora,Food Chem. 2018,263:155-162.
发表刊物:Food Chem.
关键字:Anti-inflammation; COX-2; Farnesyl phenol; Ganoderma duripora; MAPK; NF-κB.
摘要:Ganoderma fungi have long been used as a famous traditional medicine and food in country of East Asia. In this work, two new farnesyl phenolic compounds, ganoduriporols A and B (1 and 2), were isolated from the fruiting bodies of Ganoderma duripora, and their structures were elucidated using various spectroscopic methods. Anti-inflammatory activities were assayed and evaluated for the two compounds. Ganoduriporols A and B exhibited dose-dependent anti-inflammatory effects in RAW 264.7 cells. Furthermore, ganoduriporol A was demonstrated to inhibit the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) through the suppression of COX-2, MAPK and NF-κB signaling pathway in LPS-induced macrophage cells. These results suggested that these two new farnesyl phenolic compounds and the fruiting body of G. duripora could serve as anti-inflammatory agents for medicinal use or functional food.
论文类型:基础研究
是否译文:否
发表时间:2018-10-15
上一条: Wang, C.-F., Liu, X.M., Lian, C.L., Ke, J.Y., & Liu, J.Q.*. Triterpenes and Aromatic Meroterpenoids with Antioxidant Activity and Neuroprotective Effects from Ganoderma lucidum. Molecules, 2019, 24(23), 4353.
下一条: Jie-Qing Liu*, Ying Xu, Qin Xiao, Jin-Di Huang, Jun-Jie Ma, Chen-Lei Lian, Mei-Ying Huang, Zhen-bo Du and Cui-Fang Wang*. Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas. Organic Biomolecular Chemistry. 2018, 16(37): 8305-8310.
欢迎您访问我们的网站,您是第 位访客
泉州校区地址:福建省泉州市丰泽区城华北路269号 邮编:362021
厦门校区地址:福建省厦门市集美区集美大道668号 邮编:361021