主要研究方向：

      针对肿瘤等重大疾病的临床需求，基于致病靶点的结构和机制，通过合理物设计、合成和评价，获得兼具良好成药性和生物活性的“候选药物分子”。

承担课程：现代仪器分析（色谱部分）；药物化学；药物设计与合成。

科研项目（主持）：

1.    泉州市高层次人才创新创业项目，2024QZC005YR，2024/11-2027/10。

2. 福建省自然科学基金面上项目，2021J01309，2021/11-2024/11。

3.      泉州市科技计划项目，2018C074R，2018/08-2021-08。

4.      华侨大学中青年教师科技创新资助计划，ZQN-PY519，2017/10-2021/10。

5.      福建省自然科学基金面上项目，2017J01143，2017/04-2020/04。

6.      国家自然科学青年基金，81602970，2017/01-2019/12。

科研论文

(第一作者/通讯作者)：

1.   Yuan, Dandan; Gao, Yali; Xia, Lin; Liu, Han; Wu, Xingye; Ding, Xueyan; Huang, Yudan; Deng, Changchun; Li, Jin; Dai, Wenqi; Liu, Jieqing; Ma, Junjie; Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, 40(1): 2461190.

2.    He Li, Yali Gao, Xin Ni, Yizu Xiong, Peixi Zhang, Han Liu, Xingye Wu, Dandan Tong, Cuifang Wang & Junjie Ma. Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators. Mol Divers, 2025, 29, 163-177. 

3.      X. Wu, H. Li, H. Liu, X. Ding, X. Chen, C. Yin, Y. Gao, J. Ma, Design, Synthesis and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists. ACS Medicinal Chemistry Letters, 2024, 15,  518–523.

4.      Yali Gao*, Fei Li, Xin Ni, Siwang Yang, Han Liu, Xingye Wu, Jieqing Liu and Junjie Ma. Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat. RSC Adv., 2023,13, 28462-28480.

5.     Roufen Chen, Yali Gao, Han Liu, He Li, Wenfa Chen and Junjie Ma. Advances in research on 3C-like protease (3CLpro) inhibitors against SARS-CoV-2 since 2020. RSC Med. Chem., 2023,14, 9-21.

6.     He Li, Yali Gao, and Junjie Ma. Advances in nonclassical phenyl bioisosteres for drug structural optimization. Future Medicinal Chemistry 2022 14, 1681-1692.

7.   Yu. Wang, Huang. Kun, Yali. Gao, Dandan. Yuan, Lin. Ling, Jieqing. Liu, Sihai. Wu, Roufen. Chen, He. Li, Yizu. Xiong, Han. Liu, Junjie. Ma, Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction, European Journal of Medicinal Chemistry, 2022, 229, 113998.

8.  Roufen Chen, Dandan Yuan, JunJie Ma, Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy, Future Med. Chem., 2022, 14(2), 97-113.

9.   Junjie Ma, Xin Ni, Yali Gao, Kun Huang, Jiaan liu, Yu Wang, Roufen Chen, Cuifang Wang*. Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3, MedChemComm, 2019, 10(3), 465-477.

10.  Junjie Ma, Xin Ni, Yali Gao, Kun Huang, Yu Wang, Jiaan Liu, Guowei Gong*. Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Chemical & Pharmaceutical Bulletin, 2019, 67(4), 351-360.

11.   Junjie Ma, Kun Huang, Xin Ni, Roufen Chen, Boxuan Xu & Cuifang Wang*. Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety, Chem. Res. Chinese Universities, 2019, 35, 410-417.

12.  马俊杰, 倪欣, 黄坤, 王瑜, 含苯并噻唑/苯基片段的香豆素衍生物的设计、合成及抗肿瘤活性研究, Acta Pharmaceutica Sinica(药学学报), 2019, 54(3), 514 −521.

13.  倪欣, 黄坤, 马俊杰. Procaspase-3 小分子激活剂的研究进展, 中国现代应用药学, 2019, 36(3), 368-371.

（参与作者）

1.      Si-Hai Wu*, Rong Yang, Bin Sun, Jian-Hong Tang, Zhong-Liang Gong, Junjie Ma, Lianhui Wang, Jieqing Liu, Dian-Xue Ma, Jiang-Yang Shao*, and Yu-Wu Zhong*. Dual-Emissive Tris-Heteroleptic Ruthenium Complexes: Tuning the DNA-Triggered Ratiometric Emission Response by Ancillary Ligands. Inorg. Chem. 2021, 60, 19, 14810–14819.

2.      Si-Hai Wu*, Jiang-Yang Shao, Zifeng Zhao, Junjie Ma, Rong Yang, Na Chen, Jian-Hong Tang*, Zuqiang Bian, and Yu-Wu Zhong*. Ligand Engineering toward Deep Blue Emission in Nonplanar Terdentate Platinum(II) Complexes. Organometallics 2021, 40, 2, 156–165.

3.      Shao, Jiang-Yang; Wu, Si-Hai; Ma, Junjie; Gong, Zhong-Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu-Wu. Ratiometric detection of amyloid-beta aggregation by a dual-emissive tris-heteroleptic ruthenium complex, Chem. Commun., 2020, 56, 2087-2090.

4.      Jie-Qing Liu*, Ying Xu, Qin Xiao, Jin-Di Huang, Jun-Jie Ma, Chen-Lei Lian, Mei-Ying Huang, Zhen-bo Du and Cui-Fang Wang*, Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas, Org. Biomol. Chem., 2018,16, 8305-8310.

授权专利：

1.      马俊杰，刘接卿，袁丹丹，陈柔芬，一种含异羟肟酸结构的联苯类化合物及其应用，ZL 202211121782.5.

2.      马俊杰，王瑜，陈柔棻，刘接卿，吴四海，一种苯并芳杂环化合物及其用途，ZL 202110222639. 4.

3.      马俊杰, 倪欣. 一种吲哚类衍生物及其应用, ZL 201911217790.8.

4.      马俊杰, 黄坤, 倪欣, 陈柔棻, 余楚丹, 闫琦慧, 陈思颖, 侯晓林. 一种香豆素类衍生物及其应用, ZL 201811131802.0.

5.      马俊杰, 倪欣, 黄坤, 王翠芳. 一种用作caspase-3激活剂的香豆素类衍生物及其应用, ZL 201810631499.4.

硕士研究生培养情况：

倪欣：国家奖学金、三好学生、承志英才新生奖学金、二等学业奖学金、“华侨大学互联网+”大学生创新创业大赛主赛道创意组铜奖、26届“挑战杯”华侨大学学生课外学术科技作品竞赛中获得“二等奖”、福建省“创青春”大赛优秀奖。

黄坤：华侨大学“互联网+”大学生创新创业大赛主赛道创意组铜奖、三等学业奖学金、二等学业奖学金。

陈柔棻：攻读浙江大学博士、华侨大学优秀毕业生、华侨大学大学生标兵（校长特别奖）、教育部台湾学生奖学金-特等奖、华侨大学港澳台侨研究生奖学金-特等奖、华侨大学优秀学生干部、教育部“以青春之志 筑强国之路”主题征文一等奖、福建省台湾学生专项奖学金、华侨大学港澳台侨优秀研究生“承志英才”奖学金。

李贺：攻读河南大学博士。

刘寒：华侨大学优秀毕业生、校优秀学生2次，华侨大学学生社区优秀学生骨干。