基本信息

徐冬旸｜生命科学博士

副教授，硕士生导师（招收药学专业学硕，欢迎邮件咨询）

邮箱：xudongyang@hqu.edu.cn

地址：福建省厦门市集美区集美大道668号华侨大学厦门校区泛华科技楼B201

研究方向

方向一：功能基因组学，基于CRISPR/Cas13等反向遗传学技术和慢病毒插入突变文库筛选等正向遗传学方法，结合高通量测序和生物信息学分析，对基因组中的长链非编码RNA及参与抗癌药物耐药作用的新基因和新转录本进行功能鉴定，尤其关注低丰度和非经典转录本。

方向二：基因组学新方法新技术开发，通过基因组特征性序列标记和捕获，结合高通量测序技术，开发基因组学研究方法和技术，主要研究对象包括全基因组范围内的DNA损伤、基因组中的单链DNA区域，以及线粒体DNA复制起点等。

方向三：细菌抗噬菌体防御系统挖掘，通过生物信息学分析挖掘细菌的抗噬菌体防御系统，探究细菌的免疫及抗感染机制。

教育经历

2014/10-2017/09，北海道大学，博士

2010/09-2013/06，华南理工大学，硕士

2006/09-2010/06，北京林业大学，学士

科研与学术工作经历

2024/1-今，华侨大学，医学院，副教授

2017/12-2023/12，华侨大学，医学院，讲师

科研项目

1、国家自然科学基金，青年科学基金项目，24万元，主持

2、福建省自然科学基金面上项目，10万元，主持

3、华侨大学中青年教师科技创新资助计划，40万元，主持

4、华侨大学高层次人才科研启动费项目，12万元，主持

5、福建省自然科学基金重点项目，30万元，参与

6、国家自然科学基金，面上项目，58万元，参与

研究论文

第一、通讯作者

1. Pingping Huang^#, Jingxian Liu^#, Lijie Guo^#, Dongyang Xu^#, Lingbo Shen, Purui Yan, Chen Tong, Wenying Fei, Mengjun Cheng, Zhaoxing Li, Meiling Lu, Lei Zhang, Nannan Wu*, Lianwen Qi*, Yibei Xiao*, Meirong Chen*. The antiphage mechanism of a widespread trypsin-MBL defense module. Nature Chemical Biology, 2026. (Nature子刊，共同第一作者，中科院一区Top)

2. Dongyang Xu, Lu Tang, Philipp Kapranov*, Identification of Functionally-relevant lentivirus integration sites in an insertional mutagenesis cell library, Journal of Visualized Experiments, 2025, e67552.

3. Lu Tang, Dongyang Xu*, Philipp Kapranov*, RACE-Nano-Seq: profiling transcriptome diversity of a genomic locus, Bio-protocol, 2025, e5374. (共同通讯作者)

4. Lu Tang, Dongyang Xu*, Lingcong Luo, Weiyan Ma, Xiaojie He, Yong Diao, Rongqin Ke*, Philipp Kapranov*, A novel human protein-coding locus identified using a targeted RNA enrichment technique, BMC Biology, 2024, 22: 273. (共同通讯作者) (中科院一区Top)

5. Dongyang Xu^#, Lu Tang^#, Junjun Zhou, Fang Wang, Huifen Cao, Yu Huang, Philipp Kapranov*, Evidence for widespread existence of functional novel and non-canonical human transcripts. BMC Biology, 2023, 21: 271. (中科院一区Top)

6. Dongyang Xu, Lu Tang, Philipp Kapranov*, Complexities of mammalian transcriptome revealed by targeted RNA enrichment techniques. Trends in Genetics, 2023, 39: 329-333. (Cell子刊，中科院一区Top)

7. Dongyang Xu, Yu Huang, Lingcong Luo, Lu Tang, Meng Lu, Huifen Cao, Fang Wang, Yong Diao, Liudmila Lyubchenko, Philipp Kapranov*, Genome-wide profiling of endogenous single-stranded DNA using the SSiNGLe-P1 method. International Journal of Molecular Sciences, 2023, 24, 12062.

8. Dongyang Xu^#, Lingcong Luo^#, Yu Huang, Meng Lu, Lu Tang, Yong Diao, Philipp Kapranov*, Dynamic patterns of mammalian mitochondrial DNA replication uncovered using SSiNGLe-5'ES. International Journal of Molecular Sciences, 2023, 24, 9711.

9. Huifen Cao^#, Dongyang Xu^#, Ye Cai^#, Xueer Han^#, Lu Tang, Fan Gao, Yao Qi, Dingding Cai, Huifang Wang, Maxim Ri, Denis Antonets, Yuri Vyatkin, Yue Chen, Xiang You, Fang Wang, Estelle Nicolas, Philipp Kapranov*, Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans, BMC Biology, 2021, 19: 108. (共同第一作者) (中科院一区Top)

10. Fan Gao, Ye Cai, Philipp Kapranov*, Dongyang Xu*, Reverse-genetics studies of lncRNAs—what we have learnt and paths forward, Genome Biology, 2020, 21: 93. (中科院一区Top)

11. Dongyang Xu^#, Ye Cai^#, Lu Tang, Xueer Han, Fan Gao, Huifen Cao, Fei Qi, Philipp Kapranov*, A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response, Scientific Reports, 2020, 10: 1794.

12. Dongyang Xu, Yan Deng, Rongdong Fan, Lei Shi, Jianshan Bai*, He Yan*, Coresistance to benzalkonium chloride disinfectant and heavy metal ions in Listeria monocytogenes and Listeria innocua swine isolates from China, Foodborne Pathogens and Disease, 2019, 16: 696-703.

13. Yang Zhang^#, Dongyang Xu^#, Lei Shi, Rujian Cai, Chunling Li, He Yan*, Association between agar type, virulence factors, biofilm formation and antibiotic resistance of Staphylococcus aureus isolates from pork, Frontiers in Microbiology, 2018, 9: 1876. (共同第一作者) (中科院二区Top)

14. Dongyang Xu, Jiahang Miao, Emi Yumoto, Takao Yokota, Masashi Asahina, Masaaki Watahiki*, YUCCA9-mediated auxin biosynthesis and polar auxin transport synergistically regulate regeneration of root systems following root cutting, Plant and Cell Physiology, 2017, 58: 1710-1723. (封面文章)

15. Dongyang Xu, Qing Nie, Wenyan Wang, Lei Shi, He Yan*, Characterization of a transferable bcrABC and cadAC genes-harboring plasmid in Listeria monocytogenes strain isolated from food products of animal origin, International Journal of Food Microbiology, 2016, 217: 117-122. (中科院一区Top)

16. Dongyang Xu, Yanli Li, M. Shamim Hasan Zahid, Shinji Yamasaki, Lei Shi, Jianrong Li*, He Yan*, Benzalkonium chloride and heavy-metal tolerance in Listeria monocytogenes from retail foods, International Journal of Food Microbiology, 2014, 190: 24-30. (中科院一区Top)

参与作者

1. Fang Wang^#, Huifen Cao^#, Qiu Xia^#, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov*, Lessons from discovery of true ADAR RNA editing sites in a human cell line, BMC Biology, 2023, 21: 160. (中科院一区Top)

2. Huifen Cao, Yufei Zhang, Ye Cai, Lu Tang, Fan Gao, Dongyang Xu, Philipp Kapranov*, Hotspots of single-strand DNA "breakome" are enriched at transcriptional start sites of genes, Frontiers in Molecular Biosciences, 2022, 9: 895795.

3. Yue Chen^#, Fei Qi^#*, Fan Gao, Huifen Cao, Dongyang Xu, Kourosh Salehi-Ashtiani and Philipp Kapranov*, Hovlinc is a recently evolved class of ribozyme found in human lncRNA, Nature Chemical Biology, 2021, 17: 601-607. (中科院一区Top)

4. Huifen Cao^#, Lorena Salazar-Garcia^#, Fan Gao, Thor Wahlestedt, Chunlin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, Dingding Cai, Huifang Wang, Mario P.S. Chin, James A. Timmons, Claes Wahlestedt*, Philipp Kapranov*, Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells, Nature Communications, 2019, 10: 5799. (中科院一区Top)

5. He Yan, Dongyang Xu, Hecheng Meng, Lei Shi, Lin Li*, Food poisoning by clenbuterol in China, Quality Assurance and Safety of Crops & Foods, 2014, 7: 27-35.

授权专利

Method for detecting single strand breaks in DNA，US11898200B2，美国，2024，排名第5。

一种检测DNA中的单链断裂的方法，CN110628886B，中国，2022，排名第5。

课程教学

1、 肿瘤生物学（本科生课程）

2、 分子肿瘤学（本科生课程，中文及全英文）

3、 工业及药物生物技术（本科生课程，全英文）

4、 医学伦理学（本科生课程）

5、 生物医学工程进展（硕士生课程）

6、 科技文献写作专题（硕士生课程）