马俊杰
副教授 硕士生导师
主要研究方向：
针对疾病的临床需求，基于致病靶点的结构和机制，通过合理设计、合成和评价，获得兼具良好成药性和生物活性的“候选药物分子”。
2012.9 -- 2015.7
[1]沈阳药科大学 | 药物化学 | 博士研究生 | 博士学位
2020.1 -- 至今 华侨大学 | 医学院 | 副教授
2015.7 -- 2019.12 华侨大学 | 医学院 | 讲师
[1]泉州市高层次人才创新创业项目,2024/11/01-2027/10/01
[2]福建省自然科学基金面上项目,2021/11/01-2024/11/01
[3]泉州市科技计划项目,2018/08/01-2021/08/01
[4]华侨大学中青年教师科技创新资助计划,2017/10/01-2021/10/01
[5]福建省自然科学基金面上项目,2017/04/01-2020/04/01
[6]国家自然科学青年基金,2017/01/01-2019/12/01
[1]Design, synthesis, evaluation and molecular modeling of quinazoline derivatives bearing amino acids as small-molecule PD-L1 inhibitors.[J].Journal of Computer-Aided Molecular Design,2025,39:55.
[2]Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors.[J].Journal of Enzyme Inhibition and Medicinal Chemistry,2025,40(1):2461190.
[3]Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists.ACS Medicinal Chemistry Letters,2024,15518-523.
[4]Advances in nonclassical phenyl bioisosteres for drug structural optimization.Future Medicinal Chemistry,2022,141681-1692.
[5]Advances in research on 3C-like protease (3CLpro) inhibitors against SARS-CoV-2 since 2020.RSC Med. Chem.,2022,149-21.
[6]Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction.European Journal of Medicinal Chemistry,2022,229113998.
[7]Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy.Future Med. Chem.,2021,1497-113.
[8]Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety.Chem. Res. Chinese Universities,2019,35410-417.
[9]Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study.Chemical & Pharmaceutical Bulletin,2019,67351-360.
[1]仪器分析
[2]药物设计与合成
[3]药物化学
[4]波谱解析
