简介：

崔秀灵，华侨大学医学院教授。福建省闽江学者、博导，分子药物教育部工程研究中心主任、福建省分子医学重点实验室主任、精准医学与分子诊断福建省高校重点实验室主任、厦门市海洋与基因工程重点实验室主任，“国家111”计划“靶向分子医学与基因治疗”创新引智基地（培育）负责人，地球资源部“厦门市海洋小分子药物中间体与蛋白质纳米配方创新协同中心”负责人，科技部高端外国专家引进计划“金属催化脱氢偶联反应研究及其应用”负责人。开创了内置氧化剂脱氢偶联反应，发展了被国际同行称为的崔-吴偶联反应、崔氏三氮唑合成反应和崔氏烯胺酮人名反应和试剂。自2021年连续四年分别入选2020、2021、2022、2023年度Elsevier高被引国际科学家，连续多年入选全球10万杰出科学家名录。

研究方向：有机合成、小分子靶向性抗病毒药物、海洋药物和分子检测试剂盒研发

 

近年承担科研项目：

（1）福厦泉国家自主创新示范区项目，200万

（2）国家自然科学基金面上项目，无外加氧化剂的C-H键官能团化反应研究，78万

（3）国家海洋公益（平台），厦门市海洋小分子药物中间体与蛋白质纳米配方创新协同中心，500万

（4）厦门市科技局，医药中间体或天然产物中一些杂环化合物的绿色构筑，75万 

（5）国家海洋公益（项目），海洋抗乙肝抗病毒药物研发，312.39万

个人成就：

曾获得河南省科技进步一等奖、教育部高等学校科学研究优秀成果二等奖、河南省教育厅科技成果一等奖、福建省青年科技奖和泉州市优秀创新人才、福建省自然科学三等奖。

已在Chem Soc Rev、JACS、Angew Chem、Chem Sci、ACS Catal、Chem Commu、Org Lett、Cancers、Marine Drugs等高水平杂志上发表近 220 篇论文。申请专利 63 项，其中 36 项发明专利已授权。

[1]One-Pot Regiospecific Synthesis of Quinoxalines via a CH2-Extrusion Reaction.2015JCR-大类-化学1区:ORGANIC LETTERS,2015,

[2]One-Pot Regiospecific Synthesis of Quinoxalines via a CH2-Extrusion Reaction.2015JCR-大类-化学1区:ORGANIC LETTERS,2015,

[3]Iridium-Catalyzed Direct ortho-C-H Amidation of Benzaldehydes through N-Sulfonyl Imines as Mask.2015JCR-大类-化学1区:ORGANIC LETTERS,2015,

[4]Iridium-Catalyzed Direct ortho-C-H Amidation of Benzaldehydes through N-Sulfonyl Imines as Mask.2015JCR-大类-化学1区:ORGANIC LETTERS,2015,

[5]Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines.2015JCR-大类-化学2区:ORGANIC & BIOMOLECULAR CHEMISTRY,2015,

[6]Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines.2015JCR-大类-化学2区:ORGANIC & BIOMOLECULAR CHEMISTRY,2015,

[7]Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity.2015JCR-大类-医学4区:ARCHIV DER PHARMAZIE,2015,

[8]Cobalt-Catalyzed Selective Synthesis of Isoquinolines Using Picolinamide as a Traceless Directing Group.2016JCR大类-化学1区:ORGANIC LETTERS,2016,

[9]Cobalt-Catalyzed Selective Synthesis of Isoquinolines Using Picolinamide as a Traceless Directing Group.2016JCR大类-化学1区:ORGANIC LETTERS,2016,

[10]Easy access to 3-indolyl 1,1,2,2-ethanetetracarboxylates from malonates and indoles catalyzed by Pd(OAc)2.2015JCR-大类-化学3区:TETRAHEDRON,2015,

[11]Easy access to 3-indolyl 1,1,2,2-ethanetetracarboxylates from malonates and indoles catalyzed by Pd(OAc)2.2015JCR-大类-化学3区:TETRAHEDRON,2015,

[12]Base-mediated regiospecific cascade synthesis of N-(2-pyridyl)pyrroles from N-propargylic beta-enaminones.2015JCR-大类-化学2区:RSC Advances,2015,

[13]Base-mediated regiospecific cascade synthesis of N-(2-pyridyl)pyrroles from N-propargylic beta-enaminones.2015JCR-大类-化学2区:RSC Advances,2015,

[14]Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions.2015JCR-大类-化学1区:CHEMICAL COMMUNICATIONS,2015,

[15]Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions.2015JCR-大类-化学1区:CHEMICAL COMMUNICATIONS,2015,

[16]Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines.2015JCR-大类-化学2区:JOURNAL OF ORGANIC CHEMISTRY,2015,

[17]Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines.2015JCR-大类-化学2区:JOURNAL OF ORGANIC CHEMISTRY,2015,

[18]Facile synthesis of 1-aminoindoles via Rh(III)catalysed intramolecular three-component annulation.2016JCR大类-化学2区:ORGANIC CHEMISTRY FRONTIERS,2016,42179-2183.

[19]Facile synthesis of 1-aminoindoles via Rh(III)catalysed intramolecular three-component annulation.2016JCR大类-化学2区:ORGANIC CHEMISTRY FRONTIERS,2016,42179-2183.

[20]Rh(III)-Catalyzed Synthesis of Multisubstituted Isoquinolines from Benzylamines and Diazo Compounds.2016JCR大类-化学4区:CHEMISTRYSELECT,2016,

[21]Efficient and Selective Synthesis of (E)-Enamides via Ru(II)-Catalyzed Hydromidation of Internal Alkynes.2015JCR-大类-化学1区:ACS Catalysis,2015,

[22]Efficient and Selective Synthesis of (E)-Enamides via Ru(II)-Catalyzed Hydromidation of Internal Alkynes.2015JCR-大类-化学1区:ACS Catalysis,2015,

[23]Rh-Catalyzed Regioselective ortho-C-H Carbenoid Insertion of Diarylazines.2016JCR大类-化学2区:JOURNAL OF ORGANIC CHEMISTRY,2016,828611-8616.

[24]Rh-Catalyzed Regioselective ortho-C-H Carbenoid Insertion of Diarylazines.2016JCR大类-化学2区:JOURNAL OF ORGANIC CHEMISTRY,2016,828611-8616.

[25]Iridium(III)-Catalyzed One-Pot Access to 1,2-Disubstituted Benzimidazoles Starting from Imidamides and Sulfonyl Azides.2016JCR大类-化学1区:ORGANIC LETTERS,2016,194343-4346.

[26]Iridium(III)-Catalyzed One-Pot Access to 1,2-Disubstituted Benzimidazoles Starting from Imidamides and Sulfonyl Azides.2016JCR大类-化学1区:ORGANIC LETTERS,2016,194343-4346.

[27]Iridium-catalysed direct sulfamidation of quinazolinones.ROYAL SOC CHEMISTRY:RSC Advances,2017,88450-8454.

[28]The base-promoted synthesis of multisubstituted benzo[b][1,4]oxazepines.2015JCR-大类-化学1区:CHEMICAL COMMUNICATIONS,2015,

[29]The base-promoted synthesis of multisubstituted benzo[b][1,4]oxazepines.2015JCR-大类-化学1区:CHEMICAL COMMUNICATIONS,2015,

[30]Construction of Fused Polyheterocycles through Sequential [4+2] and [3+2] Cycloadditions.2016JCR大类-化学1区:ORGANIC LETTERS,2016,

[31]Construction of Fused Polyheterocycles through Sequential [4+2] and [3+2] Cycloadditions.2016JCR大类-化学1区:ORGANIC LETTERS,2016,

[32]Iridium-catalyzed Direct ortho-C-H Amidation of Benzoic Acids with Sulfonylazides.2015JCR-大类-化学4区:CHINESE CHEMICAL LETTERS,2014,

[33]The Base-Promoted Synthesis of Multisubstituted Benzo[b][1,4]oxazepines.Chem Commun,2015,

[34]One-Pot Regiospecific Synthesis of Quinoxalines via a CH2‑Extrusion Reaction.Organic Letters,2015,

[35]Biological evaluation of ferrocenyl olefins: cancer cell growth inhibition, ROS production and apoptosis activity.Archiv der Pharmazie,2015,

[36]Direct Phosphonation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions.Chemical Communications,2015,

[37]Base-Mediated Regiospecific Cascade Synthesis of N-(2-Pyridyl)pyrroles from N-Propargylic β-Enaminones.RSC Advances,2015,

[38]Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines.The Journal of Organic Chemistry (ACS Publications),2015,

[39]Practical access to 1,3,5-triarylbenzenes from chalcones and DMSO.2014JCR-大类-化学-三区:RSC Advances,2014,

[40]Practical access to 1,3,5-triarylbenzenes from chalcones and DMSO.2014JCR-大类-化学-三区:RSC Advances,2014,

[41]Transition-Metal-Catalyzed Direct C-H Functionalization under External-Oxidant-Free Conditions.2014JCR-大类-化学-三区:SYNTHESIS-STUTTGART,2014,

[42]Transition-Metal-Catalyzed Direct C-H Functionalization under External-Oxidant-Free Conditions.2014JCR-大类-化学-三区:SYNTHESIS-STUTTGART,2014,

[43]Rhodium(III)-Catalyzed C-H Activation/Alkyne Annulation by Weak Coordination of Peresters with O-O Bond as an Internal Oxidant.2014JCR-大类-化学-二区:ORGANIC LETTERS,2014,

[44]Rhodium(III)-Catalyzed C-H Activation/Alkyne Annulation by Weak Coordination of Peresters with O-O Bond as an Internal Oxidant.2014JCR-大类-化学-二区:ORGANIC LETTERS,2014,

[45]Base-Promoted β-C(sp3)-H Functionalization of Enaminones: An Approach to Polysubstituted Pyridines.2014JCR-大类-化学-二区:JOURNAL OF ORGANIC CHEMISTRY,2014,

[46]Base-Promoted β-C(sp3)-H Functionalization of Enaminones: An Approach to Polysubstituted Pyridines.2014JCR-大类-化学-二区:JOURNAL OF ORGANIC CHEMISTRY,2014,

[47]Copper-Catalyzed Synthesis of 2-Arylquinazolinones from 2-Arylindoles with Amines or Ammoniums.2014JCR-大类-化学-二区:JOURNAL OF ORGANIC CHEMISTRY,2014,

[48]Copper-Catalyzed Synthesis of 2-Arylquinazolinones from 2-Arylindoles with Amines or Ammoniums.2014JCR-大类-化学-二区:JOURNAL OF ORGANIC CHEMISTRY,2014,

[49]Progress in Recent Study of Anti-HBV Natural Products and Extracts.SCI 四区:MINI-REVIEWS IN ORGANIC CHEMISTRY,2012,

[50]Progress in Recent Study of Anti-HBV Natural Products and Extracts.MINI-REVIEWS IN ORGANIC CHEMISTRY,2012,

[51]Progress in Recent Study of Anti-HBV Natural Products and Extracts.MINI-REVIEWS IN ORGANIC CHEMISTRY,2012,

[52]Synthesis of esters from aldehydes or carboxylic acids with dichloromethane, dichloroethane or dichloropropane under mild conditions.SCI 三区:RSC Advances,2012,

[53]Synthesis of esters from aldehydes or carboxylic acids with dichloromethane, dichloroethane or dichloropropane under mild conditions.SCI 三区:RSC Advances,2012,

[54]"One pot" regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions.SCI 二区:CHEMICAL COMMUNICATIONS,2012,

[55]"One pot" regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions.SCI 二区:CHEMICAL COMMUNICATIONS,2012,

[56]Palladium-Catalyzed Oxidative CrossCoupling of N-Tosylhydrazones with Indoles: Synthesis of N-Vinylindoles.SCI 二区:ORGANIC LETTERS,2012,

[57]Palladium-Catalyzed Oxidative CrossCoupling of N-Tosylhydrazones with Indoles: Synthesis of N-Vinylindoles.SCI 二区:ORGANIC LETTERS,2012,

[58]A metal-free synthesis of diaryl-1,2-diketones by C–C triple bond cleavage of alkynones.Organic Chemistry Frontiers,2013,

[59]HBV病毒复制机制及慢性乙型肝炎药物靶点.中国药理学会:中国药理学通报,2014,

[60]Cleavage of the C-C Triple Bond of the Ketoalkynes: Synthesis of 4(3H)-Quinazolinones.Organic Chemistry Frontiers,2014,

[61]Easily Modified Directing Groups for the Palladium-Catalyzed C-H Functionalization(易修饰诱导基作用下的钯催化C—H键官能团化反应).SCI 四区:CHINESE JOURNAL OF ORGANIC CHEMISTRY,2011,

[62]Domino Reactions Based on Pd-Catalyzed C-H Bond Activation(基于钯催化C—H键活化的多米诺反应).SCI 四区:PROGRESS IN CHEMISTRY,2011,

[63]Palladium-Catalyzed Oxidative Cross-Coupling of N-Tosylhydrazones with Indoles: Synthesis of N-Vinylindoles.ORGANIC LETTERS,2012,

[64]“One pot” regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions.CHEMICAL COMMUNICATIONS,2012,

[65]Tandem synthesis of 3-allyl-chromones from alkynones and allylic alcohols under metal-free conditions.SCI 二区:CHEMICAL COMMUNICATIONS,2013,

[66]Tandem synthesis of 3-allyl-chromones from alkynones and allylic alcohols under metal-free conditions.SCI 二区:CHEMICAL COMMUNICATIONS,2013,

[67]KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water.SCI三区:ORGANIC & BIOMOLECULAR CHEMISTRY,2013,

[68]KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water.SCI三区:ORGANIC & BIOMOLECULAR CHEMISTRY,2013,

[69]A catalyst-free, facile and efficient approach to cyclic esters: synthesis of 4H-benzo[d][1,3]dioxin-4-ones.SCI 三区:RSC Advances,2013,

[70]A catalyst-free, facile and efficient approach to cyclic esters: synthesis of 4H-benzo[d][1,3]dioxin-4-ones.SCI 三区:RSC Advances,2013,

[71]天然药物抗HBV作用机制的研究进展.中国药理学与毒理学杂志,2011,

[72]易合成、易修饰的诱导基作用下的Pd催化的C-H键功能化反应.有机化学,2011,

[73]Efficient Approach to 4-Sulfonamido- quinolines via Copper(I)-Catalyzed Cascade Reaction of Sulfonyl Azides with Alkynyl Imines.Organic letters,2012,

[74]Progress in Recent Study of Anti-HBV Natural Products and Extracts.MINI-REVIEWS IN ORGANIC CHEMISTRY,2012,

[75]Progress in Recent Study of Anti-HBV Natural Products and Extracts.MINI-REVIEWS IN ORGANIC CHEMISTRY,2012,

[1] 《化学快报》理事、高级编委；《Green Catal Synth.》、《有机化学》编委

[1]有机化学实验

[2]#有机化学实验

[3]#有机化学

[4]有机化学

[5]医用化学

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