学位：理学博士学位
学历：博士研究生
职称：教授
所在单位：医学院
学术荣誉：
1、教学工作：先后承担学院5门本科生课程，教学中能够根据教学内容和学生类别，采用灵活多样的教学方式，因此入选“华侨大学2016-2018学年”“学生最喜爱的教师”。
2、学生科创：近三年指导学生获得校级及以上各类科创竞赛或创新项目14项：全国大学生生命科学竞赛一等奖、第11届全国大学生电子商务“创新、创意及创业”挑战赛三等奖、第七届全国青年科普创新实验暨作品大赛（生物环境组）福建赛区一等奖和三等奖各1个、学校第28届“挑战杯”赛特等奖等。
3、科研工作：深入企业需求，主持多项政府和企业课题10余项，经费达到300余万元并注重本科生的科研培养，将科研反哺教学。
4、社会服务：担任学院工会主席；先后担任学院药学系和实验教学中心的主任；担任农工党华大总支主委、泉州市政协委员；同时还兼职多个学术团体的委员、秘书长等。
Wang, C. F.; Xu, W. J.; Xu, Y.; Wang, Y. X.; Liu, J. Q.*, Transcriptomic analyses reveal antiinflammatory mechanism of with anolides derived from the fruits of Physalis alkekengi L. var. franchetii. Phytotherapy Research 2021, 35 (5), 2568-2578.
发表刊物：Phytotherapy Research
关键字：Physalis alkekengi L. var. franchetii; RNA-sequencing; antiinflammatory activity; withanolide.
摘要：In China, the fruits of Physalis alkekengi L. var. franchetii, which are conventionally utilized as edible berry, have attracted wide attention due to its significant biological activities. In the present study, phytochemical studies on the fruits of Physalis plants afforded six compounds, including two new withanolides (1-2) and four known agnologues (3-6). The inhibitory effects of these compounds on the formation of nitric oxide (NO) stimulated by lipopolysaccharide (LPS) in RAW264.7 macrophages were evaluated. Physapubescin M (1), with IC50 value of 1.58 μM, was selected for further study. The protein expression of COX-2 and iNOS, and LPS-induced production of cytokines (IL-6, IL-1β and TNF-α) were reduced by physapubescin M (1) in a dose-dependent way. In addition, transcriptomic analyses were conducted to profile gene expression alterations in LPS-induced RAW264.7 cells upon treatment of physapubescin M (1) and the potential antiinflammatory mechanism of withnolides was mentioned. These results provide broad view to the underlying antiinflammatory mechanism of withnolides, and give a theoretical basis for the utilization of the fruits of P. alkekengi L. var. franchetii.
论文类型：基础研究
是否译文：否
发表时间：2019-12-22
上一条： Wang, X.-H.#; Liu, J.-Q.#; Chen, S.Y.; Chen, S.; Yin, Y.F.; Liu, Y.; Zhang, C.H.*, Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake's toxicity. Commun Biol 2020, 3 (1), 228.
下一条： Xu, W.-J.; Xiao, Q.; Lian, C.-L.; Zhang, C.; Liu, J.-Q.*, The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E. Steroids 2021, 166, 108776.
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