华侨大学刘接卿--中文主页-- Wang, X.-H.#; Liu, J.-Q.#; Chen, S.Y.; Chen, S.; Yin, Y.F.; Liu, Y.; Zhang, C.H.*, Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake's toxicity. Commun Biol 2020, 3 (1), 228.

个人信息

教师姓名：刘接卿

学位：理学博士学位

学历：博士研究生

职称：教授

所在单位：医学院

学术荣誉：

泉州市高端海洋人才引进资助项目中的海洋课题研究项目

曾获荣誉：

个人简介

1、教学工作：先后承担学院5门本科生课程，教学中能够根据教学内容和学生类别，采用灵活多样的教学方式，因此入选“华侨大学2016-2018学年”“学生最喜爱的教师”。

2、学生科创：近三年指导学生获得校级及以上各类科创竞赛或创新项目14项：全国大学生生命科学竞赛一等奖、第11届全国大学生电子商务“创新、创意及创业”挑战赛三等奖、第七届全国青年科普创新实验暨作品大赛（生物环境组）福建赛区一等奖和三等奖各1个、学校第28届“挑战杯”赛特等奖等。

3、科研工作：深入企业需求，主持多项政府和企业课题10余项，经费达到300余万元并注重本科生的科研培养，将科研反哺教学。

4、社会服务：担任学院工会主席；先后担任学院药学系和实验教学中心的主任；担任农工党华大总支主委、泉州市政协委员；同时还兼职多个学术团体的委员、秘书长等。

论文成果

当前位置 : 中文主页 >> 科学研究 >> 论文成果

Wang, X.-H.#; Liu, J.-Q.#; Chen, S.Y.; Chen, S.; Yin, Y.F.; Liu, Y.; Zhang, C.H.*, Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake's toxicity. Commun Biol 2020, 3 (1), 228.

发表刊物：Commun Biol

摘要：The toxic kernel cake of Jatropha curcas (KCakeJ) is an emerging health and environmental concern. Although phorbol esters are widely recognized as the major toxin of KCakeJ, convincing evidence is absent. Here, we show that rather than phorbol esters an isomeric mixture of 11-hydroxy-9E-octadecenoic acid, 12-hydroxy-10E-octadecenoic acid and 12-hydroxy-10Z-octadecenoic acid (hydroxy-octadecenoic acids, molecular formula C18H34O3) is the major toxic component. The toxicities of hydroxy-octadecenoic acids on experimental animals, e.g. acute lethality, causing inflammation, pulmonary hemorrhage and thrombi, allergies, diarrhea and abortion, are consistent with those on human/animals caused by Jatropha seed and/or KCakeJ. The hydroxyl group and the double bond are essential for hydroxy-octadecenoic acids' toxicity. The main pathway of the toxicity mechanism includes down-regulating UCP3 gene expression, promoting ROS production, thus activating CD62P expression (platelet activation) and mast cell degranulation. The identification of the major toxin of KCakeJ lays a foundation for establishing an environmentally friendly Jatropha biofuel industry.

论文类型：基础研究

是否译文：否

发表时间：2020-05-08

上一条： Huang, J.-D.; Wang, C.-F.; Lian, C.-L.; Huang, M.-Y.; Zhang, C.; Liu, J.-Q.*, Isolation and identification of five new diterpenoids from Jatropha curcas. Phytochem. Lett. 2020, 40, 37-41.

下一条： Wang, C. F.; Xu, W. J.; Xu, Y.; Wang, Y. X.; Liu, J. Q.*, Transcriptomic analyses reveal antiinflammatory mechanism of with anolides derived from the fruits of Physalis alkekengi L. var. franchetii. Phytotherapy Research 2021, 35 (5), 2568-2578.