王连会

副教授

职称:  副教授 硕士生导师

性别:男

学历:博士研究生

学位:理学博士学位

入职时间:2014-07-17

所在单位:华侨大学医学院

办公地点:福建省泉州市丰泽区城华北路269号,华侨大学医学院德润楼113实验室

电子邮箱:

在职信息:在岗

学科:有机化学

个人简介

王连会

华侨大学医学院 副教授,硕士生导师

通讯地址:福建省泉州市丰泽区城华北路269号,华侨大学医学院德润楼113实验室

E-mail: lianhui.wang@hqu.edu.cn

研究方向:

绿色有机合成与医学应用;光驱动功能有机分子合成。

教育经历:

2010/10–2014/2 德国哥廷根大学化学学院,有机化学,博士,导师:Lutz Ackermann 教授

2007/9–2010/7 郑州大学化学系,有机化学,硕士,导师:朱志兀教授

2003/9–2007/7 郑州大学化学系,化学,学士

科研与学术工作经历:

2014/7– 华侨大学生物医学学院讲师、副教授,硕士生导师

主讲课程:

【本科生】《有机化学》,《有机化学实验》,《医用化学(有机部分)》,《化学史话》(校通识课)

【研究生】《功能有机分子的设计与合成》,《现代药学实验技术》

承担科研项目:

1. 福建省自然科学基金面上项目(2023J01129),基于光/镍协同催化的新型烯烃双官能团化反应在功能有机分子构建中的应用研究,2023.08-2026.086万元,主持。

2. 泉州市高层次人才创新创业项目(2023C012YR),光驱动烯烃串联的糖基化反应便捷构筑医药分子骨架的研究,2023.09-2026.08,10万元,主持。

3. 泉州市科技计划项目(2018C073R),烯基叠氮参与的氮杂环医药分子骨架构筑,2018.12-2021.1220万元,主持。

4. 国家自然科学基金青年项目(21602064),膦-磷叶立德双齿配体介导的 C–H 键官能团化反应研究,2017.01-2019.1220万元,主持。

5. 福建省自然科学基金面上项目(2015J01056),基于过渡金属催化 C–H 键活化的氧化偶联反应研究,2015.04-2018.064万元,主持。

6. 中央高校基本科研业务费(ZQN-PY317),易修饰导向基作用下的直接 C–H 键活化反应研究,2015.10-2019.0940万元,主持。

荣誉获奖:

福建省高层次人才C类(2023),福建省高校杰出青年科研人才培育计划(2018),泉州市“海纳百川”高端人才聚集计划(2015)。

主要发表文章:

22. C. Gong, J. Huang, L. Cai, Y. Yuan, T. Pu, M. Huang, S.-H. Wu*, L. Wang*Visible-light-promoted thiolation of benzyl chlorides with thiosulfonates via a photoactive electron donor−acceptor complex  J. Org. Chem.202489, DOI: 10.1021/acs.joc.4c00748.

21. S.-H. Wu*, Z. Zhang, R.-H. Zheng, R. Yang, L. Wang*, J.-Y. Shao, Z.-L. Gong*, Y.-W. Zhong, Dual-emissive monoruthenium complexes of N(CH3)-bridged ligand: synthesis, characterization, and substituent effect. Materials, 2023, 16, 6792.

20. H. Wang, H. Huang, C. Gong, Y. Diao, J. Chen, S.-H. Wu*, L. Wang*, Nickel-catalyzed chemo- and regioselective benzylarylation of unactivited alkenes with o-bromobenzyl chlorides. Org. Lett., 2022, 24, 328−333.

19. H. Huang, H. Wang, C. Gong, Z. Zhuang, W. Feng, S.-H. Wu*, L. Wang*, Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral [3+3] annulation between anilines and CF3-ynones using traceless directing group. Org. Chem. Front., 2022, 9, 413−419.

18. M. Yang, J. Wang, W. Lv, D. Ba, G. Cheng*, L. Wang*, Synthesis of 2-alkenyl-4H-3,1-benzoxazin-4-ones through HFIP-mediated decarboxylative [4+2]-annulation of isatoic anhydrides with cyclopropenones under silver catalysis. Adv. Synth. Catal., 2021, 363, 4085−4090.

17. J. Wang, D. Ba, M. Yang, G. Cheng*, L. Wang*, Regioselective synthesis of 2,4-diaryl-6-trifluoromethylated pyridines through copper-catalyzed cyclization of CF3-ynones and vinyl azides. J. Org. Chem., 2021, 86, 6423−6432.

16. Z. Shi, L. Wang*, Z. Yang, L. Jie, X. Liu, X. Cui*, Tandem construction of indole-fused phthalazines from (2-alkynylbenzylidene)hydrazines under metal-free conditions. J. Org. Chem., 2020, 85, 3029−3040.

15. W. Fu, L. Wang*, Z. Yang, J.-S. Shen, F. Tang, J. Zhang, X. Cui*, Facile access to versatile aza-macrolides through iridium-catalysed cascade allyl-amination/macrolactonization. Chem. Commun., 2020, 56, 960−963.

14. Z. Shi, L. Wang*, X. Cui*, Recent advances in the I2-catalyzed C−H bond functionalizations. Chin. J. Org. Chem., 2019, 39, 1596−1612.

13. L. Jie, L. Wang*, D. Xiong, Z. Yang, D. Zhao, X. Cui*, Synthesis of 2‑arylindoles through Pd(II)-catalyzed cyclization of anilines with vinyl azides. J. Org. Chem., 2018, 83, 10974−10984.

12. D. Xiong, L. Wang*, L. Jie, Z. Yang, L. Li, X. Cui*, Rhodium-catalyzed mild C7-amination of indolines with nitrosobenzenes. ChemistrySelect, 2018, 3, 13497–13500.

11. L. Wang, D. Xiong, L. Jie, C. Yu, X. Cui*, Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C–H activation: facile synthesis of benzo[g]indolines. Chin. Chem. Lett., 2018, 29, 907–910.

10. L. Wang, Y. Yu, M. Yang, C. Kuai, D. Cai, J. Yu, X. Cui*, Rhodium-catalyzed synthesis of multiaryl-substituted naphthols via a removable directing group. Adv. Synth. Catal., 2017, 359, 3818−3825.

9. L. Wang, Z. Yang, M. Yang, M. Tian, C. Kuai, X. Cui*, Facile route to ortho-hydroxyanilnes through an IrIII-catalyzed direct C–H amidation of 2-phenoxypyridines. Chem. Asian J., 2017, 12, 2634–2643.

8. L. Wang, Z. Yang, M. Yang, R. Zhang, C. Kuai, X. Cui*, Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes. Org. Biomol. Chem., 2017, 15, 8302−8307.

7. L. Wang, K. Rauch, A. V. Lygin, S. I. Kozhushkov, L. Ackermann*, Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization in water: synthesis of ethyl (E)-3-(2-acetamido-4-methylphenyl)acrylate. Org. Synth., 2015, 92, 131–147.

6. L. Wang, L. Ackermann*, Ruthenium-catalyzed ortho-C–H halogenations of benzamides. Chem. Commun., 2014, 50, 1083–1085.

5. L. Wang, L. Ackermann*, Versatile pyrrole synthesis through ruthenium(II)-catalyzed alkene C–H bond functionalization on enamines. Org. Lett., 2013, 15, 176–179.

4. L. Ackermann*, L. Wang, A. V. Lygin, Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles. Chem. Sci., 2012, 3, 177–180.

3. L. Ackermann*, L. Wang, R. Wolfram, A. V. Lygin, Ruthenium-catalyzed oxidative C–H alkenylations of anilides and benzamides in water. Org. Lett., 2012, 14, 728–731.

2. L. Wang, X. Cui*, J. Li, Y. Wu, Z. Zhu, Y. Wu*, Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle. Eur. J. Org. Chem., 2012, 595–603.

1. L. Wang, J. Li, X. Cui*, Y. Wu, Z. Zhu, Y. Wu*, Cyclopalladated ferrocenylimine as efficient catalyst for the syntheses of arylboronate esters. Adv. Synth. Catal., 2010, 352, 2002–2010.

授权发明专利:

3. 王连会,王吉鑫,程国林,一种2,4-二芳基-6-三氟甲基吡啶衍生物的制备方法,2020.10.13,中国,ZL202011089203.4

2. 王连会,施兆江,崔秀灵,一种吲哚并[2,1-a]酞嗪衍生物的制备方法,2019.2.1,中国,ZL201910106178.7

1. 王连,崔秀灵,揭亮华, 一种N-2-吡啶/嘧啶基)吲哚衍生物的制备方法,2018.1.8,中国,ZL201810017134.2

教育经历

[1] 2010.10-2014.1
德国哥廷根大学 | 有机化学 | 博士研究生 | 博士学位
[2] 2007.9-2010.6
郑州大学 | 有机化学 | 硕士研究生毕业 | 硕士学位
[3] 2003.9-2007.6
郑州大学 | 化学 | 大学专科毕业 | 学士学位

工作经历

[1] 2019.1-至今
医学院 | 华侨大学 
[2] 2014.7-2018.12
生物医学学院 | 华侨大学