Journal:ORGANIC LETTERS
Abstract:A novel and efficient approach to 4-sulfonamidoquinolines via copper-catalyzed cascade reaction of sulfonyl azides with alkynyl imines has been developed in which a 1,3-dipole cycloaddition/ketenimine formation/6π-electrocyclization/[1,3]-H shift cascade reaction was involved. Various 4-sulfonamidoquinolines were afforded in up to 84% yield for 19 examples. This synthetic strategy features with atom economy, concise steps, easy operation, and mild reaction conditions.
Volume:15
Issue:7
Page Number:1480-1483
Translation or Not:no
Date of Publication:2012-12-03
First Author:CXL,Guolin Cheng