华侨大学马俊杰--华侨大学医学院马俊杰--首页

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马俊杰

副教授硕士生导师
性别：男
学历：博士研究生
学位：理学博士学位
入职时间：2015-07-16
所在单位：华侨大学医学院
电子邮箱：
在职信息：在岗

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个人简介

主要研究方向：

针对疾病的临床需求，基于致病靶点的结构和机制，通过合理设计、合成和评价，获得兼具良好成药性和生物活性的“候选药物分子”。

教育经历

[1] 2012.9 -- 2015.7
沈阳药科大学药物化学博士研究生博士学位

工作经历

[1] 2020.1 -- 至今
华侨大学医学院副教授

[2] 2015.7 -- 2019.12
华侨大学医学院讲师

科研项目

[1]泉州市高层次人才创新创业项目,2024/11/01-2027/10/01

[2]福建省自然科学基金面上项目,2021/11/01-2024/11/01

[3]泉州市科技计划项目,2018/08/01-2021/08/01

[4]华侨大学中青年教师科技创新资助计划,2017/10/01-2021/10/01

[5]福建省自然科学基金面上项目,2017/04/01-2020/04/01

[6]国家自然科学青年基金,2017/01/01-2019/12/01

论文成果

[1]Design, synthesis, evaluation and molecular modeling of quinazoline derivatives bearing amino acids as small-molecule PD-L1 inhibitors.[J].Journal of Computer-Aided Molecular Design,2025,39:55.

[2]Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors.[J].Journal of Enzyme Inhibition and Medicinal Chemistry,2025,40(1):2461190.

[3]Design, Synthesis, and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists.ACS Medicinal Chemistry Letters,2024,15518-523.

[4]Advances in nonclassical phenyl bioisosteres for drug structural optimization.Future Medicinal Chemistry,2022,141681-1692.

[5]Advances in research on 3C-like protease (3CLpro) inhibitors against SARS-CoV-2 since 2020.RSC Med. Chem.,2022,149-21.

[6]Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction.European Journal of Medicinal Chemistry,2022,229113998.

[7]Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy.Future Med. Chem.,2021,1497-113.

[8]Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety.Chem. Res. Chinese Universities,2019,35410-417.

[9]Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study.Chemical & Pharmaceutical Bulletin,2019,67351-360.

授课信息

[1]仪器分析

[2]药物设计与合成

[3]药物化学

[4]波谱解析