个人简介

主要研究方向:

      针对肿瘤等重大疾病的临床需求,基于致病靶点的结构和机制,通过合理物设计、合成和评价,获得兼具良好成药性和生物活性的“候选药物分子”。

承担课程:现代仪器分析(色谱部分);药物化学;药物设计与合成。

科研项目(主持):

1.      福建省自然科学基金面上项目,2021J013092021/11-2024/11

2.      泉州市科技计划项目,2018C074R2018/08-2021-08

3.      华侨大学中青年教师科技创新资助计划,ZQN-PY5192017/10-2021/10

4.      福建省自然科学基金面上项目,2017J011432017/04-2020/04

5.      国家自然科学青年基金,816029702017/01-2019/12

科研项目(参与):

1.      国家自然科学基金面上项目,217720472018/01-2022/01,第三

2.      福建省高校产学合作项目,2019Y40072019/06-2022/06,第二

3.      福建省高校产学合作项目,2021Y40122021/11-2024/11,第二

4.      福建省自然科学基金面上项目,2021J013212021/11-2024/11,第三

5.      泉州市科技计划项目,2018C072R2018/10-2021/1,第二

6.      泉州市科技计划项目,2019C064R2019/09-2022/09,第三

科研论文

(第一作者/通讯作者)

1.   He Li, Yali Gao, Xin Ni, Yizu Xiong, Peixi Zhang, Han Liu, Xingye Wu, Dandan Tong, Cuifang Wang* & Junjie Ma*. Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators. Mol Divers (2024). https://doi.org/10.1007/s11030-024-10840-w.

2.      X. Wu, H. Li, H. Liu, X. Ding, X. Chen, C. Yin, Y. Gao*J. Ma*, Design, Synthesis and Evaluation of 8-(o-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists. ACS Medicinal Chemistry Letters, 2024, 15,  518523.

3.      Yali Gao*, Fei Li, Xin Ni, Siwang Yang, Han Liu, Xingye Wu, Jieqing Liu* and Junjie Ma*. Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat. RSC Adv., 2023,13, 28462-28480.

4.     Roufen Chen, Yali Gao, Han Liu, He Li, Wenfa Chen* and Junjie Ma*. Advances in research on 3C-like protease (3CLpro) inhibitors against SARS-CoV-2 since 2020. RSC Med. Chem., 2023,14, 9-21.

5.     He Li, Yali Gao*, and Junjie Ma*. Advances in nonclassical phenyl bioisosteres for drug structural optimization. Future Medicinal Chemistry 2022 14, 1681-1692.

6.      Yu. Wang, Huang. Kun, Yali. Gao, Dandan. Yuan, Lin. Ling, Jieqing. Liu, Sihai. Wu, Roufen. Chen, He. Li, Yizu. Xiong, Han. Liu, Junjie. Ma*, Discovery of quinazoline derivatives as novel small-molecule inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction, European Journal of Medicinal Chemistry, 2022, 229, 113998.

7.     Roufen Chen, Dandan Yuan, JunJie Ma*, Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy, Future Med. Chem., 2022, 14(2), 97-113.

8.      Junjie Ma*, Xin Ni, Yali Gao, Kun Huang, Jiaan liu, Yu Wang, Roufen Chen, Cuifang Wang*. Identification and biological evaluation of novel benzothiazole derivatives bearing a pyridine-semicarbazone moiety as apoptosis inducers via activation of procaspase-3 to caspase-3, MedChemComm, 2019, 10(3), 465-477.

9.    Junjie Ma*, Xin Ni, Yali Gao, Kun Huang, Yu Wang, Jiaan Liu, Guowei Gong*. Semicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Chemical & Pharmaceutical Bulletin, 2019, 67(4), 351-360.

10.     Junjie Ma*, Kun Huang, Xin Ni, Roufen Chen, Boxuan Xu & Cuifang Wang*. Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methyl-Biphenyl Moiety, Chem. Res. Chinese Universities, 2019, 35, 410-417.

11.  马俊杰*倪欣黄坤王瑜含苯并噻唑/苯基片段的香豆素衍生物的设计、合成及抗肿瘤活性研究, Acta Pharmaceutica Sinica(药学学报), 2019, 54(3), 514 −521.

12.  倪欣黄坤马俊杰*. Procaspase-3 小分子激活剂的研究进展中国现代应用药学, 2019, 36(3), 368-371.

13.  Junjie Ma, Guanglong Bao, Limei Wang, Wanting Li, Boxuan Xu, XinZhai, Ping Gong*. Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2015, 96, 173-186.

14.  MA Junjie, HU Gang, XIE Lijun, CHEN Lei, XU Boxuan, GONG Ping*. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents, Chemical Research in Chinese Universities, 2015, 31(6), 958-963.

15.  Junjie Ma, Dong Chen, Kuan Lu, Lihui Wang, Xiaoqi Han, Yanfang Zhao, Ping Gong*. Design, synthesis, and structureeactivity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents, European Journal of Medicinal Chemistry, 2014, 86, 257-269.

16.  Junjie Ma, Guangyan Zhang, Xiaoqi Han, Guanglong Bao, Lihui Wang, Xin Zhai,and Ping Gong*. Synthesis and Biological Evaluation of Benzothiazole Derivatives Bearing the ortho-Hydroxy-N-acylhydrazone Moiety as Potent Antitumor Agents, Arch. Pharm. Chem. Life Sci, 2014, 347(12), 936-949.

(参与作者)

1.      Si-Hai Wu*, Rong Yang, Bin Sun, Jian-Hong Tang, Zhong-Liang Gong, Junjie Ma, Lianhui Wang, Jieqing Liu, Dian-Xue Ma, Jiang-Yang Shao*, and Yu-Wu Zhong*. Dual-Emissive Tris-Heteroleptic Ruthenium Complexes: Tuning the DNA-Triggered Ratiometric Emission Response by Ancillary Ligands. Inorg. Chem. 2021, 60, 19, 14810–14819.

2.      Si-Hai Wu*, Jiang-Yang Shao, Zifeng Zhao, Junjie Ma, Rong Yang, Na Chen, Jian-Hong Tang*, Zuqiang Bian, and Yu-Wu Zhong*. Ligand Engineering toward Deep Blue Emission in Nonplanar Terdentate Platinum(II) Complexes. Organometallics 2021, 40, 2, 156–165.

3.      Shao, Jiang-Yang; Wu, Si-Hai; Ma, Junjie; Gong, Zhong-Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu-Wu. Ratiometric detection of amyloid-beta aggregation by a dual-emissive tris-heteroleptic ruthenium complex, Chem. Commun., 2020, 56, 2087-2090.

4.      Jie-Qing Liu*, Ying Xu, Qin Xiao, Jin-Di Huang, Jun-Jie Ma, Chen-Lei Lian, Mei-Ying Huang, Zhen-bo Du and Cui-Fang Wang*, Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas, Org. Biomol. Chem., 2018,16, 8305-8310.

授权专利:

1.      马俊杰,刘接卿,袁丹丹,陈柔芬,一种含异羟肟酸结构的联苯类化合物及其应用,ZL 202211121782.5.

2.      马俊杰,王瑜,陈柔棻,刘接卿,吴四海,一种苯并芳杂环化合物及其用途,ZL 202110222639. 4.

3.      马俊杰倪欣一种吲哚类衍生物及其应用, ZL 201911217790.8.

4.      马俊杰黄坤倪欣陈柔棻余楚丹闫琦慧陈思颖侯晓林一种香豆素类衍生物及其应用, ZL 201811131802.0.

5.      马俊杰黄坤王翠芳一种用作caspase-3激活剂的香豆素类衍生物及其应用, ZL 201810631499.4.

教育经历

  • 2012.9-----2015.7

    沈阳药科大学 | 药物化学 | 博士研究生 | 博士学位

工作经历

  • 2020.1-----至今

    医学院 | 华侨大学

  • 2015.7-----2019.12

    医学院 | 华侨大学

团队成员

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马俊杰

个人信息

  • 副教授

    硕士生导师
  • 性别:
  • 学历:博士研究生
  • 学位:理学博士学位
  • 入职时间:2015-07-16
  • 所在单位:华侨大学医学院
  • 电子邮箱:
  • 在职信息:在岗

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