所属单位：华侨大学
教研室：精准医疗研究中心
发表刊物：MOLECULAR MEDICINE REPORTS
刊物所在地：GREECE
关键字：exosome；miRNAs；radiotherapy；esophageal squamous cell carcinoma
摘要：Radiotherapy is one of the main treatment methods for esophageal squamous cell carcinoma (ESCC). Previous research has shown that plasma exosomal microRNAs (miRNAs) can predict therapeutic outcome. In the present study, to identify potential exosomal miRNAs that respond to radiotherapy, plasma exosomal miRNAs from ESCC patients undergoing radiotherapy were isolated and sequenced. Upregulated and downregulated miRNAs were detected from patients pre‑ and post‑radiotherapy, and it was found that they play distinct roles in DNA damage process and endosomal mediated transport. Based on wound healing and Cell Counting Kit‑8 assays in TE‑1 human esophageal cancer cells, it was identified that representative miRNA miR‑652 and miR‑30a alter migration but not proliferation. The present findings identified differentially expressed miRNAs in responding to radiotherapy, and added a reference to explore non‑invasive plasma biomarkers to evaluate therapeutic effects in ESCC.
论文类型：期刊论文
论文编号：287
卷号：26
期号：3
ISSN号：1791-2997
是否译文：否
发表时间：2022-07-22
收录刊物：SCI
DOI码：10.3892/mmr.2022.12803
影响因子：3.423
第一作者：苗楠
通讯作者：孙涛
发布期刊链接：https://www.spandidos-publications.com/mmr/26/3/287