My main research interests are immunopharmacology and neuropsychopharmacology. So far, I have published more than 60 papers as the corresponding author, with an H-index of 34, and have been selected for the 2023-2024 list of the top 2% scientists in the world by Elsevier.
1. Jun Wang, Xin-Yu Wang, Zhong-Yu Yuan, Xiao-Han Wang, Yu-Ying Guan, Ji-Xiao Zhu, Wei-Feng Huang*, Qing Liu, Guang-Hui Xu*, Li-Tao Yi*. Blueberry extract attenuates DSS-induced inflammatory bowel disease in mice through inhibiting ER stress-mediated colonic apoptosis in mice. Food & Function. 2024;15(18):9541-9551.
2. Zhong-Yu Yuan, Xuan Zhang, Zong-Zhong Yu, Xin-Yu Wang, Zi-Heng Zeng, Meng-Xuan Wei, Meng-Ting Qiu, Jun Wang, Jie Cheng, Li-Tao Yi*. Polygonatum sibiricum polysaccharides alleviate depressive-like symptoms in chronic restraint stress-induced mice via microglial regulation in prefrontal cortex. Polymers (Basel). 2024;16(16):2358.
3. Jun Wang, Zhong-Yu Yuan, Xin-Yu Wang, Ji-Xiao Zhu, Wei-Feng Huang*, Guang-Hui Xu*, Li-Tao Yi*. Anthocyanins-rich cranberry extract attenuates DSS-induced IBD in an intestinal flora independent manner. Current Research in Food Science. 2024;9:100815.
4. Rong-Cheng Xie, Jin-Cheng Zhang, Xiao-Ming Lin, Ting Huang, Yu-Ting Wang, Lian-Fang Zhang, Xiang-Yu Hong, Xue-Feng Lin, Hong-Jun Zheng, Zhe Luo, Li-Tao Yi*, Jie-Fei Ma*. Inhibition of colon C5a/C5a receptor signalling pathway confers protection against LPS-induced acute kidney injury via gut microbiota-kidney axis. European Journal of Pharmacology. 2024;969:176425.
5. Zi-Wei Ye, Zhong-Yu Yuan, Jun Wang, Hua Li, Cheng-Fu Li, Guang-Hui Xu, Li-Tao Yi*, Wei-Feng Huang*. Fucoidan attenuates chronic colitis and behavioral deficits by reshaping gut microbiota-brain axis balance. Journal of Functional Foods. 2024;112:105951.
6. Pei-Lu Chen, Guang-Hui Xu*, Ming Li, Jia-Yuan Zhang, Jie Cheng, Cheng-Fu Li, Li-Tao Yi*. Yamogenin exhibits antidepressant-like effects via inhibition of ER Stress and microglial activation in LPS-induced mice. ACS Chemical Neuroscience. 2023;14(17):3173-3182.
7. Shi-Le Wang, Man-Man Zhang, Han Zhou, Guo-Qiang Su, Yi Ding, Guang-Hui Xu, Xu Wang, Cheng-Fu Li, Wei-Feng Huang*, Li-Tao Yi*. Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation. Biomedical Journal. 2023;46(5):100580.
8. Yu Wang, Yi-Jie Liu, Man-Man Zhang, Han Zhou, Yi-Han Gao, Wen-Jing Cheng, Zi-Wei Ye, Zhong-Yu Yuan, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi*. CY-09 alleviates the depression-like behaviors via inhibiting NLRP3 inflammasome-mediated neuroinflammation in lipopolysaccharide-Induced mice. ACS Chemical Neuroscience. 2022;13(23):3291-3302.
9. Yu-Xuan Huang, Na-Fen Li, Chen-Yao Li, Fang-Ping Zheng, Xiang-Yang Yao, Bao-Hua Lin, Xian-Zhong Huang, Neng-Jiang Zhao, Jia-Yong Yang, Qiu-Min Chen, Man-Man Zhang, Li-Tao Yi*, Xue-Qin Chen*. Clinical features and effectiveness of Chinese medicine in patients with COVID-19 from overseas: A retrospective study in Xiamen, China. Frontiers in Public Health. 2022;10:1038017.
10. Jun-Ji Cui, Ze-Yun Huang, Yi-Hang Xie, Jun-Bin Wu, Guang-Hui Xu, Cheng-Fu Li*, Man-Man Zhang, Li-Tao Yi*. Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress. Journal of Affective Disorders. 2023;321:242-252.
11. Min-Xia Guo, Man-Man Zhang, Hai-Yan Yang, Chu-Ling Zhang, Hong-Yu Cheng, Na-Zhi Li, Li-Tao Yi*, Ji-Xiao Zhu*. Lagotis brachystachya maxim attenuates chronic alcoholic liver injury combined with gouty arthritis in rats via its anti-inflammatory activity. Frontiers in Pharmacology. 2022;13:995777.
12. Man-Man Zhang, Guo-Ming Huo, Jie Cheng, Qiu-Ping Zhang, Na-Zhi Li, Min-Xia Guo, Qing Liu, Guang-Hui Xu, Ji-Xiao Zhu, Cheng-Fu Li, Feng Zhou*, Li-Tao Yi*. Gypenoside XVII, an active ingredient from Gynostemma Pentaphyllum, inhibits C3aR-associated synaptic pruning in stressed mice. Nutrients. 2022;14(12):2418.
13. Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Xue-Qin Chen, Na-Zhi Li, Qing Liu, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu*, Li-Tao Yi*. IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression. Nutrients. 2022;12(1):90.
14. Qing Liu, Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Na-Zhi Li, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu*, Li-Tao Yi*. Inhibition of microglial NLRP3 with MCC950 attenuates microglial morphology and NLRP3/Caspase-1/IL-1β signaling in stress-induced mice. Journal of Neuroimmune Pharmacology. 2022;17(3-4):503-514.
15. Qiu-Ping Zhang, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi*. Dendrobium officinale polysaccharides alleviate depression-like symptoms via regulating gut microbiota-neuroinflammation in perimenopausal mice. Journal of Functional Foods. 2022;88:104912.
16. Xiang Ouyang, Na-Zhi Li, Min-Xia Guo, Man-Man Zhang, Jie Cheng, Li-Tao Yi*, Ji-Xiao Zhu*. Lagotis brachystachya maxim attenuates chronic alcoholic liver injury combined with gouty arthritis in rats via its anti-inflammatory activity. Frontiers in Pharmacology. 2021;12:760331.
17. Shuang Zhao, Cheng-Bo Rong, Yi Gao, Lin-Feng Wu, Xiao-Heng Luo, Shuang Song, Yu Liu, Jack Ho Wong, He-Xiang Wang, Li-Tao Yi*, Tzibun Ng*. Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor. Applied Microbiology and Biotechnology. 2021;105(23):8675-8688.
18. Guang-Hui Xu*, Hui-Qi Wan, Li-Tao Yi*, Wei Chen, You-Hua Luo, Yi-Qi Huang, Xiao-Juan Liu. Berberine administrated with different routes attenuates inhaled LPS-induced acute respiratory distress syndrome through TLR4/NF-κB and JAK2/STAT3 inhibition. European Journal of Pharmacology. 2021;908:174349.
19. Ji-Xiao Zhu, Hai-Yan Yang, Wei-Qiong Hu, Jie Cheng, Yang Liu, Li-Tao Yi*, Hong-Yu Cheng*. Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice. Inflammopharmacology. 2021;29(4):1187-1200.
20. Li-Tao Yi*, Man-Man Zhang, Jie Cheng, Hui-Qi Wan, Cheng-Fu Li, Ji-Xiao Zhu, Qiu-Ping Zhang, Qing Liu, Guang-Hui Xu. Antidepressant-like effects of degraded porphyran isolated from Porphyra haitanensis. Molecular Nutrition & Food Research. 2021;65(9):e2000869.
21. Jie Cheng, Min Chen, Hui-Qi Wan, Xue-Qin Chen, Cheng-Fu Li, Ji-Xiao Zhu, Qing Liu, Guang-Hui Xu*, Li-Tao Yi*. Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation. Journal of Ethnopharmacology. 2021;274:114046.
22. Li-Tao Yi*, Shuang-Shuang Wang, Jie Cheng, Min Chen, Ji-Xiao Zhu, Cheng-Fu Li, Shu-Qi Dong, Qing Liu. Sustained AMP-activated protein kinase activation attenuates the activity of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in mice exposed to chronic stress. Chinese Medical Journal. 2021;134(15):1874-1876.
23. Li-Tao Yi*, Ji-Xiao Zhu, Shu-Qi Dong, Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Qing Liu. miR-34a induces spine damages via inhibiting synaptotagmin-1 in depression. Neurobiology of Stress. 2020;13:100243.
24. Li-Tao Yi*, Ji-Xiao Zhu, Shu-Qi Dong, Min Chen, Cheng-Fu Li. Berberine exerts antidepressant-like effects via regulating miR-34a-synaptotagmin1/Bcl-2 axis. Chinese Herbal Medicines. 2020;13(1):116-123.
25. Min Chen, Qiu-Ping Zhang, Ji-Xiao Zhu, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li*, Li-Tao Yi*. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice. European Journal of Pharmacology. 2020;881:173297.
26. Li-Tao Yi*, Shu-Qi Dong, Shuang-Shuang Wang, Min Chen, Cheng-Fu Li, Di Geng, Ji-Xiao Zhu, Qing Liu, Jie Cheng. Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy. Neurobiology of Disease. 2020;136:104715.
27. Jie Cheng, Min Chen, Ji-Xiao Zhu, Cheng-Fu Li, Qiu-Ping Zhang, Di Geng, Qing Liu, Li-Tao Yi*. FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin. Biochemical Pharmacology. 2019;168:91-99.
28. Shu-Qi Dong, Shuang-Shuang Wang, Ji-Xiao Zhu, Rong-Hao Mu, Cheng-Fu Li, Di Geng, Qing Liu, Li-Tao Yi*. Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice. Steroids. 2019;149:108419.
29. Ji-Xiao Zhu, Wei-Qiong Hu, Shu-Qi Dong, Li-Tao Yi*, Jin-Xiang Zeng, Min Li*. Hippocampal BDNF signaling is required for the antidepressant effects of perillaldehyde. Pharmacological Reports. 2019;71(3):430-437.
30. Lian-Jin Weng, Shu-Qi Dong, Shuang-Shuang Wang, Li-Tao Yi*, Di Geng*. Macranthol attenuates lipopolysaccharide-induced depressive-like behaviors by inhibiting neuroinflammation in prefrontal cortex. Physiology & Behavior. 2019;204:33-40.
31. Shu-Qi Dong, Qiu-Ping Zhang, Ji-Xiao Zhu, Min Chen, Cheng-Fu Li, Qing Liu, Di Geng, Li-Tao Yi*. Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation. Biomedicine & Pharmacotherapy. 2018;106:1153-1160.
32. Xue-Qin Chen, Cheng-Fu Li, Shu-Jiao Chen, Wen-Na Liang, Miao Wang, Shuang-Shuang Wang, Shu-Qi Dong, Li-Tao Yi*, Can-Dong Li*. The antidepressant-like effects of Chaihu Shugan San: Dependent on the hippocampal BDNF-TrkB-ERK/Akt signaling activation in perimenopausal depression-like rats. Biomedicine & Pharmacotherapy. 2018:105:45-52.
33. Li-Tao Yi*, Rong-Hao Mu, Shu-Qi Dong, Shuang-Shuang Wang, Cheng-Fu Li, Di Geng, Qing Liu. miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice. Journal of Psychopharmacology. 2018;32(4):458-468.
34. Xue-Qin Chen, Shu-Jiao Chen, Wen-Na Liang, Miao Wang, Cheng-Fu Li, Shuang-Shuang Wang, Shu-Qi Dong, Li-Tao Yi*, Can-Dong Li*. Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress. Neuroscience Letters. 2018:662:283-289.
35. Ya-Min Liu, Le Niu, Lin-Lin Wang, Li Bai, Xiao-Yan Fang, Yu-Cheng Li*, Li-Tao Yi*. Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. Brain Research Bulletin. 2017;134:220-227.
36. Shuang-Shuang Wang, Rong-Hao Mu, Cheng-Fu Li, Shu-Qi Dong, Di Geng, Qing Liu, Li-Tao Yi*. microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2017;79(Pt B):417-425.
37. Cheng-Fu Li, Xue-Qin Chen, Shao-Mei Chen, Xue-Mei Chen, Di Geng, Qing Liu, Li-Tao Yi*. Evaluation of the toxicological properties and anti-inflammatory mechanism of Hemerocallis citrina in LPS-induced depressive-like mice. Biomedicine & Pharmacotherapy. 2017:91:167-173.
38. Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li*, Li-Tao Yi*. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International Immunopharmacology. 2017:45:128-134.
39. Ya-Min Liu, Chun-Yue Hu, Ji-Duo Shen, Su-Hui Wu, Yu-Cheng Li*, Li-Tao Yi*. Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression. Physiology & Behavior. 2017:169:184-188.
40. Rong-Hao Mu, Xiao-Yan Fang, Shuang-Shuang Wang, Cheng-Fu Li, Shao-Mei Chen, Xue-Mei Chen, Qing Liu, Yu-Cheng Li, Li-Tao Yi*. Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus. Psychopharmacology (Berl). 2016;233(17):3211-3221.
41. Cheng-Fu Li, Shao-Mei Chen, Xue-Mei Chen, Rong-Hao Mu, Shuang-Shuang Wang, Di Geng, Qing Liu, Li-Tao Yi*. ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress. Brain Research Bulletin. 2016;124:40-47.
42. Le Li, Yu-Meng Li, Zhen-Ling Liu, Jian-Gang Zhang, Qing Liu, Li-Tao Yi*. The renal protective effects of Anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin. Journal of Ethnopharmacology. 2016;178:58-65.
43. Cheng-Fu Li, Xue-Mei Chen, Shao-Mei Chen, Rong-Hao Mu, Bin-Bin Liu, Liu Luo, Xiao-Long Liu, Di Geng, Qing Liu, Li-Tao Yi*. Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid. Brain Research. 2016;1630:73-82.
44. Xiao-Long Liu, Liu Luo, Rong-Hao Mu, Bin-Bin Liu, Di Geng, Qing Liu, Li-Tao Yi*. Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. Scientific Reports. 2015;5:16024.
45. Li-Tao Yi*, Liu Luo, Yong-Jing Wu, Bin-Bin Liu, Xiao-Long Liu, Di Geng, Qing Liu. Circadian variations in behaviors, BDNF and cell proliferation in depressive mice. Metabolic Brain Disease. 2015;30(6):1495-503.
46. Liu Luo, Xiao-Long Liu, Jing Li, Rong-Hao Mu, Qing Liu, Li-Tao Yi*, Di Geng*. Macranthol promotes hippocampal neuronal proliferation in mice via BDNF-TrkB-PI3K/Akt signaling pathway. European Journal of Pharmacology. 2015;762:357-363.
47. Liu Luo, Xiao-Long Liu, Rong-Hao Mu, Yong-Jing Wu, Bin-Bin Liu, Di Geng, Qing Liu, Li-Tao Yi*. Hippocampal BDNF signaling restored with chronic asiaticoside treatment in depression-like mice. Brain Research Bulletin. 2015;114:62-69.
48. Jian-Gang Zhang, Qing Liu, Zhen-Ling Liu, Le Li, Li-Tao Yi*. Antihyperglycemic activity of Anoectochilus roxburghii polysaccharose in diabetic mice induced by high-fat diet and streptozotocin. Journal of Ethnopharmacology. 2015;164:180-5.
49. Bin-Bin Liu, Liu Luo, Xiao-Long Liu, Di Geng, Cheng-Fu Li, Shao-Mei Chen, Xue-Mei Chen, Li-Tao Yi*, Qing Liu. Essential oil of Syzygium aromaticum reverses the deficits of stress-induced behaviors and hippocampal p-ERK/p-CREB/brain-derived neurotrophic factor expression. Planta Medica. 2015;81(3):185-192.
50. Li-Tao Yi*, Jing Li, Bin-Bin Liu, Liu Luo, Qing Liu, Di Geng. BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice. Journal of Psychiatry & Neuroscience. 2014;39(5):348-359.
51. Bin-Bin Liu, Liu Luo, Xiao-Long Liu, Di Geng, Qing Liu, Li-Tao Yi*. 7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress. Psychopharmacology (Berl). 2015;232(3):541-550.
52. Xiao-Long Liu, Liu Luo, Bin-Bin Liu, Jing Li, Di Geng, Qing Liu, Li-Tao Yi*. Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats. Journal of Ethnopharmacology. 2014;153(2):484-490.
53. Li-Tao Yi*, Bin-Bin Liu, Jing Li, Liu Luo, Qing Liu, Di Geng, Yue Tang, Yuan Xia, Di Wu. BDNF signaling is necessary for the antidepressant-like effect of naringenin. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2014;48:135-141.
54. Li-Tao Yi*, Jing Li, Bin-Bin Liu, Cheng-Fu Li. Screening of the antidepressant-like effect of the traditional Chinese medicinal formula Si-Ni-San and their possible mechanism of action in mice. Pharmacognosy Research. 2013;5(1):36-42.
55. Jing Li, Ying Zhou, Bin-Bin Liu, Qing Liu, Di Geng, Lian-Jin Weng, Li-Tao Yi*. Nobiletin ameliorates the deficits in hippocampal BDNF, TrkB, and Synapsin I induced by chronic unpredictable mild stress. Evidence-based Complementary and Alternative Medicine. 2013;2013:359682.
56. Jing Li, Di Geng, Jiao Xu, Lian-Jin Weng, Qing Liu, Li-Tao Yi*. Antidepressant-like effect of macranthol isolated from Illicium dunnianum tutch in mice. European Journal of Pharmacology. 2013;707(1-3):112-119.
57. Li-Tao Yi*, Jing Li, Di Geng, Bin-Bin Liu, Ying Fu, Jia-Qi Tu, Yuan Liu, Lian-Jin Weng. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. Journal of Ethnopharmacology. 2013;147(1):245-253.
58. Li-Tao Yi*, Jing Li, Qing Liu, Di Geng, Ya-Fei Zhou, Xiao-Qing Ke, Huan Chen, Lian-Jin Weng. Antidepressant-like effect of oleanolic acid in mice exposed to the repeated forced swimming test. Journal of Psychopharmacology. 2013;27(5):459-468.
59. Yu-Cheng Li, Ji-Duo Shen, Jing Li, Rui Wang, Shuo Jiao, Li-Tao Yi*. Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2013 10:40:138-43.
60. Li-Tao Yi*, Jing Li, Huo-Chen Li, Ying Zhou, Bi-Fang Su, Ke-Feng Yang, Meng Jiang, Yan-Ting Zhang. Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration. Journal of Ethnopharmacology. 2012;144(2):328-334.
61. Li-Tao Yi*, Jing Li, Dong-Xue Su, Jing-Fang Dong, Cheng-Fu Li. Hypouricemic effect of the methanol extract from Prunus mume fruit in mice. Pharmaceutical Biology. 2012;50(11):1423-7.
62. Li-Tao Yi*, Jing Li, Huo-Chen Li, Dong-Xue Su, Xia-Bo Quan, Xiao-Cheng He, Xiao-Hong Wang. Antidepressant-like behavioral, neurochemical and neuroendocrine effects of naringenin in the mouse repeated tail suspension test. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2012;39(1):175-181.
63. Lan Gu, Yan-Jun Liu, Yao-Bin Wang, Li-Tao Yi*. Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. Journal of Ethnopharmacology. 2012;139(3):780-787.
64. Li-Tao Yi*, He-Li Xu, Jing Feng, Xia Zhan, Li-Pan Zhou, Cun-Cang Cui. Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. Physiology & Behavior. 2011;102(1):1-6.
65. Li-Tao Yi*, Cheng-Fu Li, Xia Zhan, Cun-Cang Cui, Fei Xiao, Li-Pan Zhou, Yong Xie. Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2010;34(7):1223-1228.
Current position:
Research Field