Qr code
中文
Miao Nan

Associate professor

Supervisor of Master's Candidates


Gender:Female

Date of Birth:1988-11-07

Education Level:博士研究生

School/Department:华侨大学医学院

Business Address:华侨大学厦门校区泛华科技大楼B201

E-Mail:

Status:在岗

Other Post:药理学教研室主任

Discipline:Biomedical Engineering
Biomedical Engineering

Honors and Titles:

2024-07-25   全国大学生基础医学实验设计创新大赛(西部、中南部赛区) 三等奖 (指导老师)

2024-05-07   华侨大学第四届基础医学创新研究暨实验设计大赛 三等奖(指导老师)

2023-12-29   Brain Sciences 2023 Outstanding Reviewer Award

2024-04-14   医学院“精彩一堂课”三等奖

2023-06-30   2022-2023年 考核优秀

2019-06-30   2018-2019年 考核优秀

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Current position: Home >> Scientific Research >> Paper Publications
Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma

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Affiliation of Author(s):华侨大学

Teaching and Research Group:精准医疗研究中心

Journal:MOLECULAR MEDICINE REPORTS

Place of Publication:GREECE

Key Words:exosome;miRNAs;radiotherapy;esophageal squamous cell carcinoma

Abstract:Radiotherapy is one of the main treatment methods for esophageal squamous cell carcinoma (ESCC). Previous research has shown that plasma exosomal microRNAs (miRNAs) can predict therapeutic outcome. In the present study, to identify potential exosomal miRNAs that respond to radiotherapy, plasma exosomal miRNAs from ESCC patients undergoing radiotherapy were isolated and sequenced. Upregulated and downregulated miRNAs were detected from patients pre‑ and post‑radiotherapy, and it was found that they play distinct roles in DNA damage process and endosomal mediated transport. Based on wound healing and Cell Counting Kit‑8 assays in TE‑1 human esophageal cancer cells, it was identified that representative miRNA miR‑652 and miR‑30a alter migration but not proliferation. The present findings identified differentially expressed miRNAs in responding to radiotherapy, and added a reference to explore non‑invasive plasma biomarkers to evaluate therapeutic effects in ESCC.

Indexed by:Journal paper

Document Code:287

Volume:26

Issue:3

ISSN No.:1791-2997

Translation or Not:no

Included Journals:SCI

DOI number:10.3892/mmr.2022.12803

Impact Factor:3.423

First Author:苗楠

Correspondence Author:孙涛

Links to published journals:https://www.spandidos-publications.com/mmr/26/3/287