Associate professor
Supervisor of Master's Candidates
Gender:Female
Date of Birth:1988-11-07
Education Level:博士研究生
School/Department:华侨大学医学院
Business Address:华侨大学厦门校区泛华科技大楼B201
E-Mail:
Status:在岗
Other Post:药理学教研室主任
Discipline:Biomedical Engineering
Biomedical Engineering
Honors and Titles:
2024-07-25 全国大学生基础医学实验设计创新大赛(西部、中南部赛区) 三等奖 (指导老师)
2024-05-07 华侨大学第四届基础医学创新研究暨实验设计大赛 三等奖(指导老师)
2023-12-29 Brain Sciences 2023 Outstanding Reviewer Award
2024-04-14 医学院“精彩一堂课”三等奖
2023-06-30 2022-2023年 考核优秀
2019-06-30 2018-2019年 考核优秀
The Last Update Time: ..
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Affiliation of Author(s):华侨大学
Teaching and Research Group:精准医疗研究中心
Journal:MOLECULAR MEDICINE REPORTS
Place of Publication:GREECE
Key Words:exosome;miRNAs;radiotherapy;esophageal squamous cell carcinoma
Abstract:Radiotherapy is one of the main treatment methods for esophageal squamous cell carcinoma (ESCC). Previous research has shown that plasma exosomal microRNAs (miRNAs) can predict therapeutic outcome. In the present study, to identify potential exosomal miRNAs that respond to radiotherapy, plasma exosomal miRNAs from ESCC patients undergoing radiotherapy were isolated and sequenced. Upregulated and downregulated miRNAs were detected from patients pre‑ and post‑radiotherapy, and it was found that they play distinct roles in DNA damage process and endosomal mediated transport. Based on wound healing and Cell Counting Kit‑8 assays in TE‑1 human esophageal cancer cells, it was identified that representative miRNA miR‑652 and miR‑30a alter migration but not proliferation. The present findings identified differentially expressed miRNAs in responding to radiotherapy, and added a reference to explore non‑invasive plasma biomarkers to evaluate therapeutic effects in ESCC.
Indexed by:Journal paper
Document Code:287
Volume:26
Issue:3
ISSN No.:1791-2997
Translation or Not:no
Included Journals:SCI
DOI number:10.3892/mmr.2022.12803
Impact Factor:3.423
First Author:苗楠
Correspondence Author:孙涛
Links to published journals:https://www.spandidos-publications.com/mmr/26/3/287