Associate professor
Supervisor of Master's Candidates
Gender:Female
Date of Birth:1988-11-07
Education Level:博士研究生
School/Department:华侨大学医学院
Business Address:华侨大学厦门校区泛华科技大楼B201
E-Mail:
Status:在岗
Other Post:药理学教研室主任
Discipline:Biomedical Engineering
Biomedical Engineering
Honors and Titles:
2024-07-25 全国大学生基础医学实验设计创新大赛（西部、中南部赛区） 三等奖 （指导老师）
2024-05-07 华侨大学第四届基础医学创新研究暨实验设计大赛 三等奖（指导老师）
2023-12-29 Brain Sciences 2023 Outstanding Reviewer Award
2024-04-14 医学院“精彩一堂课”三等奖
2023-06-30 2022-2023年 考核优秀
2019-06-30 2018-2019年 考核优秀
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Affiliation of Author(s):华侨大学医学院
Teaching and Research Group:精准医疗研究中心-孙涛课题组
Journal:Frontiers in Molecular Biosciences
Place of Publication:SWITZERLAND
Funded by:国自然青年基金，中青年基金
Key Words:ATAC-seq; DNA methylation; chromosomal accessibility; epigenetics; klinefelter syndrome.
Abstract:Klinefelter syndrome (KS, 47XXY) is a disorder characterized by sex chromosomal aneuploidy, which may lead to changes in epigenetic regulations of gene expression. To define epigenetic architectures in 47XXY, we annotated DNA methylation in euploid males (46XY) and females (46XX), and 47XXY individuals using whole genome bisulfite sequencing (WGBS) and integrated chromatin accessbilty, and detected abnormal hypermethylation in 47XXY. Furthermore, we detected altered chromatin accessibility in 47XXY, in particular in chromosome X, using Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) in cultured amniotic cells. Our results construct the whole genome-wide DNA methylation map in 47XXY, and provide new insights into the early epigenomic dysregulation resulting from an extra chromosome X in 47XXY.
Indexed by:Journal paper
Document Code:1128739
Volume:10
Translation or Not:no
Included Journals:SCI
DOI number:10.3389/fmolb.2023.1128739
Impact Factor:6.123
First Author:Miao Nan
Correspondence Author:SUN TAO
Links to published journals:https://doi.org/10.3389/fmolb.2023.1128739
Current position: