Associate professor
Supervisor of Master's Candidates
Gender:Female
Date of Birth:1988-11-07
Education Level:博士研究生
School/Department:华侨大学医学院
Business Address:华侨大学厦门校区泛华科技大楼B201
E-Mail:
Status:在岗
Other Post:药理学教研室主任
Discipline:Biomedical Engineering
Biomedical Engineering
Honors and Titles:
2024-07-25 全国大学生基础医学实验设计创新大赛（西部、中南部赛区） 三等奖 （指导老师）
2024-05-07 华侨大学第四届基础医学创新研究暨实验设计大赛 三等奖（指导老师）
2023-12-29 Brain Sciences 2023 Outstanding Reviewer Award
2024-04-14 医学院“精彩一堂课”三等奖
2023-06-30 2022-2023年 考核优秀
2019-06-30 2018-2019年 考核优秀
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Affiliation of Author(s):华侨大学医学院
Teaching and Research Group:精准医疗研究中心
Journal:FRONTIERS IN MOLECULAR NEUROSCIENCE
Place of Publication:SWITZERLAND
Key Words:Wnt7a，Sfrp1，cerebral cortex，neural progenitors，antagonist
Abstract:The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex.
Indexed by:Journal paper
Document Code:47
Volume:11
ISSN No.:1662-5099
Translation or Not:no
Included Journals:SCI
DOI number:10.3389/fnmol.2018.00247
Impact Factor:6.261
First Author:苗楠
Co-author:Ghulam Hussain,Zhihong Wen,Shiying Huang,Taufif Mubarak,Trevor Lee,Shan Bian
Correspondence Author:孙涛
Links to published journals:https://www.frontiersin.org/articles/10.3389/fnmol.2018.00247/full
Current position: