Affiliation of Author(s):华侨大学医学院

Journal:International Journal of Molecular Sciences

Place of Publication:SWITZERLAND

Key Words:miRNAs；fluoxetine；antidepressant；depression；hippocampus

Abstract:Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs.

Indexed by:Journal paper

Document Code:671

Volume:19

Issue:3

ISSN No.:1422-0067

Translation or Not:no

Included Journals:SCI

DOI number:10.3390/ijms19030671

Impact Factor:6.627

First Author:Miao Nan

Co-author:Seung-Nam Kim,Jun ghee Jin

Correspondence Author:SUN TAO

Links to published journals:https://doi.org/10.3390/ijms19030671