Qr code
中文
Miao Nan

Associate professor

Supervisor of Master's Candidates


Gender:Female

Date of Birth:1988-11-07

Education Level:博士研究生

School/Department:华侨大学医学院

Business Address:华侨大学厦门校区泛华科技大楼B201

E-Mail:

Status:在岗

Other Post:药理学教研室主任

Discipline:Biomedical Engineering
Biomedical Engineering

Honors and Titles:

2024-07-25   全国大学生基础医学实验设计创新大赛(西部、中南部赛区) 三等奖 (指导老师)

2024-05-07   华侨大学第四届基础医学创新研究暨实验设计大赛 三等奖(指导老师)

2023-12-29   Brain Sciences 2023 Outstanding Reviewer Award

2024-04-14   医学院“精彩一堂课”三等奖

2023-06-30   2022-2023年 考核优秀

2019-06-30   2018-2019年 考核优秀

Click:Times

The Last Update Time: ..

Current position: Home >> Scientific Research >> Paper Publications
Identification of male-biased microRNA-107 as a direct regulator for nuclear receptor subfamily 5 group A member 1 based on sexually dimorphic microRNA expression profiling from chicken embryonic gonads

Hits:

Affiliation of Author(s):华中农业大学

Journal:MOLECULAR AND CELLULAR ENDOCRINOLOGY

Place of Publication:IRELAND

Key Words:Chicken,Sex-biased miRNAs,miR-107,Gonadal development,NR5a1

Abstract:Several studies indicate that sexual dimorphic microRNAs (miRNAs) in chicken gonads are likely to have important roles in sexual development, but a more global understanding of the roles of miRNAs in sexual differentiation is still needed. To this end, we performed miRNA expression profiling in chicken gonads at embryonic day 5.5 (E5.5). Among the sex-biased miRNAs validated by qRT-PCR, twelve male-biased and six female-biased miRNAs were consistent with the sequencing results. Bioinformatics analysis revealed that some sex-biased miRNAs were potentially involved in gonadal development. Further functional analysis found that over-expression of miR-107 directly inhibited nuclear receptor subfamily 5 group A member 1 (NR5a1), and its downstream cytochrome P450 family 19 subfamily A, polypeptide 1 (CYP19A1). However, anti-Mullerian hormone (AMH) was not directly or indirectly regulated by miR-107. Overall results indicate that miR-107 may specifically mediate avian ovary-development by post transcriptional regulation of NR5a1 and CYP19A1 in estrogen signaling pathways. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Indexed by:Journal paper

Volume:429

Issue:C

Page Number:29-40

ISSN No.:0303-7207

Translation or Not:no

Included Journals:SCI

DOI number:10.1016/j.mce.2016.03.033

Impact Factor:4.467

First Author:苗楠

Co-author:侯岳,王馨

Correspondence Author:龚炎长,俸艳萍