所属单位：华侨大学
教研室：精准医疗研究中心
发表刊物：MOLECULAR BIOLOGY REPORTS
刊物所在地：NETHERLANDS
关键字：Brain asymmetry；miRNAs；Cerebral cortex；WNT signaling pathway；Lateralization
摘要：Human brain is anatomically and functionally asymmetric. How brain asymmetry is initiated and established during fetal development is poorly understood. Accumulating evidence has shown that microRNAs (miRNAs) play crucial roles in brain development and function. In this study, we investigate miRNA expression profiles in left and right hemispheres of human fetal brains at 12 weeks post conception (PC), and identify 42 miRNAs showing differential expression between two hemispheres using Affymetrix microarray analyses. Target genes for left- and right-biased miRNAs are largely involved in developmental and functional regulations in the cortex such as axon guidance, GABAergic synapse and dopaminergic synapse pathways. Moreover, we find that predicted targets associated with canonical and non-canonical WNT signaling pathway show variations and differential expression between two hemispheres in response to left- and right-biased miRNAs. Our results highlight a potential role of miRNAs in regulating asymmetric development of human fetal brains.
论文类型：期刊论文
卷号：47
期号：9
页面范围：6573-6586
ISSN号：0301-4851
是否译文：否
发表时间：2020-08-31
收录刊物：SCI
DOI码：10.1007/s11033-020-05708-9
影响因子：2.742
第一作者：苗楠
发布期刊链接：https://link.springer.com/article/10.1007/s11033-020-05708-9