所属单位：华侨大学医学院
教研室：精准医疗研究中心
发表刊物：FRONTIERS IN MOLECULAR NEUROSCIENCE
刊物所在地：SWITZERLAND
关键字：Wnt7a，Sfrp1，cerebral cortex，neural progenitors，antagonist
摘要：The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex.
论文类型：期刊论文
论文编号：47
卷号：11
ISSN号：1662-5099
是否译文：否
发表时间：2018-07-17
收录刊物：SCI
DOI码：10.3389/fnmol.2018.00247
影响因子：6.261
第一作者：苗楠
合写作者：Ghulam Hussain,Zhihong Wen,Shiying Huang,Taufif Mubarak,Trevor Lee,Shan Bian
通讯作者：孙涛
发布期刊链接：https://www.frontiersin.org/articles/10.3389/fnmol.2018.00247/full