所属单位：华侨大学医学院
发表刊物：International Journal of Molecular Sciences
刊物所在地：SWITZERLAND
关键字：miRNAs；fluoxetine；antidepressant；depression；hippocampus
摘要：Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, we here investigate changes of expression levels of hippocampal microRNAs (miRNAs) after administration of fluoxetine in normal adult mice. We find that 64 miRNAs showed significant changes between fluoxetine treatment and control groups by analyzing 626 mouse miRNAs. Many miRNAs in response to fluoxetine are involved in neural-related signaling pathways by analyzing miRNA-target gene pairs using the Kyoto encyclopedia of genes and genomes (KEGG) and Gene Ontology (GO). Moreover, miRNAs with altered expression are mainly associated with the repression of the dopaminergic synapse signals, which may affect hippocampal function after fluoxetine treatment. Our results demonstrate that a number of miRNAs respond to antidepressants even in normal mice and may affect target gene expression, which supports the safety consideration of inappropriate treatment and off-label use of antidepressant drugs.
论文类型：期刊论文
论文编号：671
卷号：19
期号：3
ISSN号：1422-0067
是否译文：否
发表时间：2018-02-28
收录刊物：SCI
DOI码：10.3390/ijms19030671
影响因子：6.627
第一作者：苗楠
合写作者：Seung-Nam Kim,Jun ghee Jin
通讯作者：孙涛
发布期刊链接：https://doi.org/10.3390/ijms19030671